EMA Puts Temporary Restrictions on Tofacitinib Due to PE Risk EMA Puts Temporary Restrictions on Tofacitinib Due to PE Risk
The EMA's safety committee advises physicians not to prescribe the 10-mg twice-daily dose of tofacitinib to patients who are at high risk for pulmonary embolism, pending results of an ongoing safety review.News Alerts
PMID: 31205114 [PubMed - in process]
CONCLUSIONS: Findings suggest that gaps of VTE care extend in different levels of the medical system, including: the patient, physicians, and medical teams. Patients were sensitive to a lack of disease awareness among healthcare providers. There was appreciation for subspecialty care recommended for VTE. In a qualitative study, using the patient perspective, we have detected frustrations and perceived areas of improvement of the care of the patient with VTE. These gaps are anchored in perceived lack of disease awareness and difficult transitional care. PMID: 31203596 [PubMed - as supplied by publisher]
We describe a recent case of silicone embolism syndrome occurring together with systemic tuberculosis in a transgendered patient newly diagnosed with AIDS. She presented with fever, hematochezia, lymphadenopathies, purple nodular lesions and lower limb edema. HIV test was positive. A chest X-Ray showed interstitial infiltrates and a tomography showed necrotic lymph nodes and pulmonary nodules with blurred borders, suggesting Kaposi sarcoma. Psychomotor impairment then occurred in the absence of tomographic signs of acute neurological events. The Mycobacterium tuberculosis genome was isolated from stool and bronchial washin...
Conditions: Pulmonary Embolism With Acute Cor Pulmonale; Pulmonary Embolism; Pulmonary Embolism With Pulmonary Infarction; Pulmonary Embolism Subacute Massive; Right Ventricular Dysfunction; Right Ventricular Failure Interventions: Drug: Alteplase; Drug: Unfractionated heparin; Drug: Placebo; Drug: Apixaban Sponsors: Victor Tapson, MD; Bristol-Myers Squibb Not yet recruiting
Given a good enough data set, there are ways to produce evidence for causation in the observed relationships between patient characteristics and risk of age-related disease. While it is well accepted by now that being overweight does in fact cause a raised risk of all the common age-related diseases, a shorter life expectancy, and a raised lifetime medical expenditure, more data never hurts. Researchers have a good understanding of the mechanisms involved in these relationships. In particular, visceral fat tissue around the abdominal organs generates chronic inflammation, which acts to accelerate tissue decline and age-rel...
ConclusionAcute organophosphate poisoning treated with atropine showed a potential for inducing prothrombotic coagulation abnormalities, presented with PT. This life-threatening complication may additionally contribute to prolonged morbidity and mortality in OP poisonings, especially in patients with medical history of comorbidites.
Publication date: Available online 14 June 2019Source: Respiratory Medicine Case ReportsAuthor(s): Takashi Ishiguro, Keisuke Matsuo, Shinya Fujii, Noboru TakayanagiAbstractA 58-year-old man with previous myocardial infarction presented to our hospital with fever, cough, and dyspnea. PCR testing with nasopharyngeal swabs confirmed influenza virus infection, and enhanced computed tomography and transthoracic echocardiography revealed bilateral ground-glass opacities and consolidation, deep venous thrombosis, acute pulmonary artery embolism, and acute arterial embolism that appeared to originate from thrombus in the left vent...
CONCLUSION: Compared with csDMARDs and/or steroids without ABT, adding ABT to the treatment does not appear to increase the incidence rates of postoperative adverse events in RA patients undergoing orthopedic surgery. Large cohort studies should be performed to add evidence for the perioperative safety profile of ABT. PMID: 31203226 [PubMed - as supplied by publisher]
A 69-year-old man with a history of rheumatoid arthritis and pulmonary fibrosis presented with an incidentally discovered 11.5 cm left renal mass with a level 3 inferior vena cava (IVC) tumor thrombus, including involvement of the left adrenal and lumbar veins. The thrombus was highly vascularized as shown in Figure 1A-C. Preoperative evaluation was negative for metastatic disease and the serum creatinine (SCr) level was 1.55 mg/dL, correlating with an estimated glomerular filtration rate (eGFR) of 46 mL/min/1.73m2.
ConclusionsCardioCel has good durability when used for the repair of congenital heart defects. It performs comparably in the systemic and pulmonary circulations in neonates, infants and older children.