Iatrogenic Kaposi sarcoma of the terminal ileum following short-term treatment with immunomodulators for Crohn disease: A case report

We report the case of a 45-year-old young woman with abdominal pain, episodic diarrhea and a mild weight loss. The patient was treated with immunosuppressive therapy for a parietal thickening of the terminal ileum, wrongly diagnosed as Crohn disease. After 9 months after the beginning of antitumor necrosis factor-α, the patient was admitted for obstructive symptoms. A computed tomography suspected neoplasia of ileocecal region. The patient underwent an uneventful ileocecal surgical resection. Diagnoses: The histopathology showed endometriosis of the ileal wall and an irrefutable diagnosis of KS by immunohistochemistry-positive staining for human herpes virus-8. Interventions and outcomes: The patient underwent surgical resection and is disease free at 6 years follow-up. Lessons: This case underlines the interaction of immunosuppressive therapy with the possible consequent development of visceral KS.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research