Osteoarthritis Secondary to Rives–Stoppa Incisional Hernia Repair
Publication date: Available online 17 May 2019Source: Cirugía Española (English Edition)Author(s): Irene Mirón Fernández, Cristina Rodríguez Silva, José Rivas Becerra, Julio Santoyo Santoyo
Conclusions: We observed a significant inverse relationship between surgeon volume and complication rates when controlling for patient and injury characteristics. In contrast to previous research, a volume–outcome relationship was not observed at the hospital level. These results suggest that such complex injuries should be triaged to the most experienced providers. Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
The latest crowdfunded research project undertaken by the SENS Research Foundation involves using the genetically engineered maximally modifiable mouse lineage in order to demonstrate the ability to copy a version of the ATP8 mitochondrial gene into the cell nucleus, a process known as allotopic expression, and thus prevent mutational damage to this gene from degrading mitochondrial function. This is a modest step on the road towards bringing this class of genetic engineering project to the point of readiness for commercial development, when a biotech startup company could be created to carry it forward. In just a f...
Authors: Morgans AK, Szymaniak BM Abstract The landscape of genetic testing for prostate cancer is rapidly evolving. There is increasing evidence that individuals with germline mutations in DNA-repair genes are more responsive to targeted therapies. Due to potential implications for treatment, these genes should be taken into consideration when determining the scope of genetic testing. PMID: 31629435 [PubMed - in process]
Authors: Carroll PR, Witte JS, Parsons JK Abstract Men with germline mutations in DNA repair genes are at an increased risk of prostate cancer. These germline mutations are commonly seen in conjunction with somatic DNA repair gene mutations in prostate tumors. This indicates that men with a personal or family history of prostate cancer-as well as other cancer syndromes arising from mutations in DNA repair genes-should be considered for genetic testing and counseling. PMID: 31629425 [PubMed - in process]
This article summarizes a presentation at the 2019 Philadelphia Consensus Conference focused on the latest data at the intersection of germline and tumor genetic testing for prostate cancer patients. PMID: 31629422 [PubMed - in process]
Authors: Knudsen KE Abstract Despite significant advances in understanding the biology of advanced prostate cancer and approval of novel therapeutic agents, there is no durable cure for metastatic disease. Recent findings unmasked the importance of androgen receptor (AR) signaling in regulation of DNA repair, and alterations of the AR-DNA repair factor axis were shown to promote aggressive phenotypes including metastasis. These and related findings underscore the importance of determining impact AR-DNA repair factor alterations on prostate cancer progression. PMID: 31629421 [PubMed - in process]
Authors: Cheng HH Abstract Recent studies demonstrate that the prevalence of germline mutations in DNA repair genes in metastatic prostate cancer is higher than previously recognized, and is higher than in localized disease and in unaffected men. This is compelling evidence that specific gene dysfunction is critical in prostate cancer initiation and/or evolution to metastases. Applications to treatment in advanced disease are imminent, and further investigation in early-stage disease, as well as in diverse and at-risk populations will help maximize clinical benefit. PMID: 31629420 [PubMed - in process]
Authors: Boyle J, Cooney KA Abstract Germline pathogenic mutations in DNA repair genes have been linked to prostate cancer risk and aggressiveness. This observation was facilitated by tumor sequencing of men with advanced prostate cancer and has important implications for clinical management. In addition, cascade testing will identify at-risk individuals who should be assessed for cancer risk. PMID: 31629416 [PubMed - in process]
Santoyo Santoyo J PMID: 31029371 [PubMed - as supplied by publisher]
We are presenting a 53 year old female with a BMI of 57. Past medical history includes OSA on CPAP, HTN, CHF, low back pain, osteoarthritis, IBS, bipolar disorder, seizure disorder and a left hepatic hemangioma that is relevant for this case. The patient had prior abdominal surgeries including laparoscopic cholecystectomy, appendectomy and 2 C-section s. She was evaluated for her morbid obesity and comorbidities and was deemed to be a good candidate for bariatric surgery. Her preoperative workout included an upper endoscopy that was normal without esophagitis. As a work up for an episode o...