Neutrophil Extracellular Traps (NETs) profiles in patients with incident SLE and lupus nephritis.

CONCLUSION: iLN patients have increased circulating NETs and reduced DNase activity, the later being explained by the presence of inhibitory substances in circulation and/or by rare DNase1L3 mutations. Accumulation of NETs derives from a multi-factorial mechanism, is associated and may contribute to disease severity in SLE, in particular to renal lesions. PMID: 31092713 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research