Low-cost pneumonia vaccine breaks into global market

Publication date: 18–24 May 2019Source: The Lancet, Volume 393, Issue 10185Author(s): Ann Danaiya Usher
Source: The Lancet - Category: General Medicine Source Type: research

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CONCLUSIONS: Our findings demonstrate that nasal colonization with pneumococcus and microaspiration prime AM, leading to brisker responsiveness to both pneumococcus and unrelated bacterial pathogens. The relative abundance of AM in the alveolar spaces, alongside with their potential for non-specific protection, render them an attractive target for novel vaccines. Clinical trial registration available at http://www.isrctn.com, ID: ISRCTN16993271. PMID: 31626559 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Outbreaks of severe pneumococcal disease occur sporadically and can affect large numbers of individuals, although they are less frequent compared to the pre-antibiotic era.1 The responsible pathogen, Streptococcus pneumoniae, is a Gram-positive bacterium that commonly colonises the nasopharyngeal tract, especially in young children. Occasionally, however, it can invade locally to cause mucosal infections including sinusitis, otitis media or pneumonia. Rarely, invasion of the bloodstream can lead to more serious infections, including septicaemia and meningitis.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
Authors: Lamichhane PP, Samarasinghe AE Abstract Influenza virus infection is a serious threat to humans and animals, with the potential to cause severe pneumonia and death. Annual vaccination strategies are a mainstay to prevent complications related to influenza. However, protection from the emerging subtypes of influenza A viruses (IAV) even in vaccinated individuals is challenging. Innate immune cells are the first cells to respond to IAV infection in the respiratory tract. Virus replication-induced production of cytokines from airway epithelium recruits innate immune cells to the site of infection. These leuko...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
PMID: 31615716 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Prospective cohort study (n=2,934) found that the incidence of pneumococcal community acquired pneumonia increased from 32.2 to 48.2 per 100 000 population, predominantly due to non-vaccine type serotype and serotype 3.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
(CNN) — Most pregnant women in the United States don’t get flu and whooping cough vaccines even though the shots are safe and recommended as part of routine prenatal care, a report from the US Centers for Disease Control and Prevention said Tuesday. The report said the low rates of vaccination during pregnancy could put moms-to-be and newborns at greater risk of infection, hospitalization and death. The two vaccinations pass on antibodies to the fetus that provide protection after birth, when babies are too young to be vaccinated. It added that pregnant women have more than double the risk of hospitalization if...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Syndicated CBSN Boston CNN Flu Vaccine Pregnancy Whooping Cough Source Type: news
ConclusionAdults who received pneumococcal vaccines experienced reduced rates of hospital versus ICU admissions due to pneumonia infection.
Source: Journal of Pharmaceutical Health Services Research - Category: Drugs & Pharmacology Authors: Tags: Research Paper Source Type: research
Publication date: Available online 4 October 2019Source: The Lancet Respiratory MedicineAuthor(s): Dina Goodman, Mary E Crocker, Farhan Pervaiz, Eric D McCollum, Kyle Steenland, Suzanne M Simkovich, Catherine H Miele, Laura L Hammitt, Phabiola Herrera, Heather J Zar, Harry Campbell, Claudio F Lanata, John P McCracken, Lisa M Thompson, Ghislaine Rosa, Miles A Kirby, Sarada Garg, Gurusamy Thangavel, Vijayalakshmi Thanasekaraan, Kalpana BalakrishnanSummaryPneumonia is a leading killer of children younger than 5 years despite high vaccination coverage, improved nutrition, and widespread implementation of the Integrated Managem...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
FRIDAY, Oct. 4, 2019 -- Many U.S. adults, including some at the highest risk for the flu and pneumonia, do not plan to get preventive vaccines, according to a survey conducted by NORC at the University of Chicago on behalf of the National Foundation...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Abstract Bovine respiratory disease (BRD) remains a major health problem despite extensive use of vaccines during the post-weaning period. Apparent vaccine failure is attributed, in part, to primary vaccination during the period of greatest risk for BRD, providing inadequate time for onset of protective immunity. The current study investigated whether intranasal (IN) vaccination of 3-6 week old calves with a modified-live viral (MLV) vaccine induced sufficient immune memory to prevent respiratory disease and accelerate onset of protective immunity 5 months later. Vaccine groups included naïve controls, a ...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
More News: General Medicine | Pneomococcal Vaccine | Pneumonia | Vaccines