Successful adjunctive use of bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa infection in a cystic fibrosis patient

ConclusionGiven the concern for MDR P. aeruginosa infections in CF patients, BT may offer a viable anti-infective adjunct to traditional antibiotic therapy.
Source: Infection - Category: Infectious Diseases Source Type: research

Related Links:

A blood test can identify a subgroup of pneumonia patients at increased risk for developing acute respiratory failure or sepsis, according to new research.Reuters Health Information
Source: Medscape Emergency Medicine Headlines - Category: Emergency Medicine Tags: Pulmonary Medicine News Source Type: news
Publication date: Available online 11 October 2019Source: Life SciencesAuthor(s): Mohammad Amin Javidi, Ayat Kaeidi, Seyedeh Sahar Mortazavi Farsani, Sadegh Babashah, Majid SadeghizadehAbstractAimsAn important obstacle on the way of cell-based therapy is the risk of tumorigenicity in the patients benefit from these transplanted cells due to undifferentiated cells which participate in transplantation. Curcumin, the main compound of spice turmeric -as one of the natural products-was demonstrated to possess effective anti-cancer properties, with no significant effect on normal cells in dose and/or time-dependent manner. Furth...
Source: Life Sciences - Category: Biology Source Type: research
We reported a case of bronchopulmonary lophomoniasis in a Malaysian female with systemic lupus erythromatosus. She presented with productive cough, shortness of breath and high-grade fever for 2 weeks. Physical examination revealed bronchial sound and crackles over the left lung with, reduced expansion and dull percussion in lower left lobe. Chest radiography showed consolidation of the left lung. Routine laboratory tests revealed general low cell count. Blood and sputum culture were negative. Bronchoalveolar lavage stain and culture for bacterial and fungal were negative. Bronchoalveolar lavage for Lophomonas blattarum wa...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Authors: Liu W, Wang K, Zhao YH, Song GP, Gao W, Li DH Abstract The aim of the present study was to investigate the potential of the Immuknow immune cell function assay for the diagnosis of infection after pediatric living-donor liver transplantation (LDLT). Based on clinical data obtained following liver transplantation, 66 patients were divided into infection (n=28) and non-infection (n=38) groups. The following factors were considered in the present analysis: Primary disease, lymphocyte count, tacrolimus plasma concentration/dose (C0/D) ratio, CD4+ T lymphocyte ATP levels, at pre-transplant stage and at weeks 1-...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: He J, Han X, Wang S, Zhang Y, Dai X, Liu B, Liu L, Zhao X Abstract Bone tissue engineering provides a substitute for bone transplantation to address various bone defects. However, bone regeneration involves a large number of cellular events. In addition, obtaining sufficient source material for autogenous bone or alloplastic bone substitutes remains an unsolved issue. In previous studies, it was confirmed that bone marrow stromal cells (BMSCs) and endothelial progenitor cells (EPCs) had the capacity to promote bone regeneration. Additionally, bone morphogenetic protein-2 (BMP-2) has been demonstrated to be...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Nseir W, Khamisy-Farah R, Amara A, Farah R Abstract BACKGROUND: The incidence of Clostridium difficile-associated diarrhea (CDAD) is increasing and is associated with significant morbidity and mortality. Therefore, there is a need to find new tools to determine the severity of the disease. OBJECTIVES: To investigate the prognostic values of inflammatory markers such as mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR), and C-reactive protein (CRP) in patients with CDAD. METHODS: The study comprised of 100 patients diagnosed with CDAD. The study included an additional control group of 69...
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
Publication date: December 2019Source: Microbial Pathogenesis, Volume 137Author(s): Seok Hyeon Na, Man Hwan Oh, Hyejin Jeon, Yun-Ki Lee, Byungheon Lee, Minsang Shin, Je Chul LeeAbstractBioluminescence imaging is a non-invasive tool for in vivo real-time monitoring of infectious disease progression in animal models. However, no bioluminescence imaging assay has been developed to monitor Acinetobacter baumannii infections. In the current study, bioluminescent strains of A. baumannii ATCC 17978 and its isogenic ΔompA mutant were constructed by integrating the promoter of the ompA gene and the luxCDABE luciferase gene in...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
This study assessed an innovative isopropyl alcohol/organofunctional silane solution (IOS) to reduce microbial contamination on inert surfaces in a medical ICU.MethodsBaseline adenosine triphosphate bioluminescence testing (ABT)-measurements (N = 200) were obtained on designated inert ICU surfaces followed by IOS treatment. At 1 and 6 weeks, selective surfaces were randomized to either IOS-treated or nontreated controls for comparison using ABT (N = 400) and RODAC colony counts (N = 400). An ABT value of ≤45 relative light units (RLU) was designated as “clean,” whereas>45 was assessed as &ldqu...
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
Publication date: Available online 8 October 2019Source: American Journal of Infection ControlAuthor(s): Katherine D. Ellingson, Brie N. Noble, Dat Tran, Genevieve L. Buser, Christopher D. Pfeiffer, P. Maureen Cassidy, Rebecca Pierce, Zintars G. Beldavs, Jon P. FurunoIn 2014, Oregon implemented an interfacility transfer communication law requiring notification of multidrug-resistant organism status on patient transfer. Based on 2015 and 2016 statewide facility surveys, compliance was 77% and 87% for hospitals, and 67% and 68% for skilled nursing facilities. Methods for complying with the rule were heterogeneous, and fewer ...
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
Conclusions: Antibiotic pharmacodynamic target attainment rates likely were not meaningfully different in the low- and high-intensity treatment arms of the Acute Renal Failure Trial Network and RENAL Replacement Therapy Study Investigators trials.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research
More News: Antibiotic Therapy | Cystic Fibrosis | Infectious Diseases | Lung Transplant | Multidrug Resistance | Pneumonia | Renal Failure | Respiratory Medicine | Transplants