Nigeria: Burden of TB in Nigeria Weighs Heavier, New Data Shows

[Africa Check] In its April 2019 article "The tuberculosis enigma", Nigeria's the Nation newspaper quotes the World Health Organization as saying the country is "first in Africa" for the burden of the disease.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news

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Publication date: Available online 15 October 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Gilla KaplanAbstractTuberculosis incidence is projected to decline at too slow a rate to meet the targets set at the UN high level meeting on ending tuberculosis, convened in New York in 2018. To understand the causes of the slow progress in tuberculosis control, the Bill and Melinda Gates Foundation supported a patient-pathway analysis that identified significant gaps with patients being “lost” at all points along the care cascade. Although each country differed in the reasons for failure, some comm...
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research
DiscussionIntestinal TB most commonly affected region is the ileocaecal, accounts for 64% of the incidence of gastrointestinal TB. The main reasons for the predilection of ileocaecal region are due to relatively longer faecal static, the abundant of lymphoid tissue, a neutral pH environment and absorptive transport mechanisms that allow swallowed mycobacterium to be absorbed. Intestinal TB may pose similar symptoms as those found in pulmonary TB, yet patients most commonly presenting with abdominal pain. Bacteriological signs and histopathological findings are gold standard for ITB diagnosis. Therapy for ITB includes pharm...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
In this study, we attempted to identify the key structural feature for highly potent GyrB inhibitors through 2D-QSAR using HQSAR, 3D-QSAR using CoMSIA and molecular dynamics (MD) simulations approaches on a series of thiazole urea core derivatives. The best HQSAR and CoMSIA models based on IC50 and MIC displayed the structural basis required for good activity against both GyrB enzyme and mycobacterial cell. MD simulations and binding free energy analysis using MM-GBSA and waterswap calculations revealed that the urea core of inhibitors has the strongest interaction with Asp79 via hydrogen bond interactions. In addition, ca...
Source: SAR and QSAR in Environmental Research - Category: Environmental Health Authors: Tags: SAR QSAR Environ Res Source Type: research
Conclusions: A six-month course of isoniazid proved to be safe and effective in the treatment of LTBI, which is essential to reducing the risk of developing active tuberculosis.RESUMO Objetivo: Descrever a incid ência de tuberculose ativa e a ocorrência de eventos adversos do tratamento com isoniazida em pacientes diagnosticados com tuberculose latente (TBL), portadores de doenças inflamatórias crônicas e tratados com agentes imunobiológicos em uma área endêmica no Brasil. Métodos: O diagnóstico de TBL foi feito com base em anamnese, exame clínico, ra...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
To describe the surgical techniques in a case of female genital tuberculosis (TB) with superimposed tubo-ovarian abscess (TOA) in a developed country.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Virtual Poster Session 1: Laparoscopy (10:00 AM — 10:10 AM) 10:00 AM: STATION P Source Type: research
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01187
Source: Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
The dual challenge of low diagnostic sensitivity of microscopy test and technical challenge of performing a TB culture test poses a problem for case detection and initiation of Tuberculosis (TB) second-line tr...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
CONCLUSIONS: We recommend implementation of this guideline in all Iranian prisons. PMID: 31613730 [PubMed - as supplied by publisher]
Source: Infectious Disorders Drug Targets - Category: Infectious Diseases Authors: Tags: Infect Disord Drug Targets Source Type: research
OMICS: A Journal of Integrative Biology, Ahead of Print.
Source: OMICS: A Journal of Integrative Biology - Category: Biology Authors: Source Type: research
Background: Previously, we have found that blockade of PD-1/PD-Ls pathway could enhance CD4+ T cells-mediated protective immunity in patients with active tuberculosis (ATB). However, the mechanism of PD-1/PD-Ls pathway involved in negative regulation of anti-TB immunity has been still unclear. Recently, the study of human immunodeficiency virus (HIV) infection demonstrated that PD-1 could induce the expression of basic leucine zipper ATF-like transcription factor (BATF) to inhibit CD8+ T cell function. While the mechanism of immune regulation of BATF in Mycobacterium tuberculosis (M. tb) infection has not yet been elucidat...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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