Risk of Developing Additional Immune-Mediated Manifestations: A Retrospective Matched Cohort Study
ConclusionsThis study demonstrates that the risk of developing a second IMID is significantly higher for individuals who have already experienced a first IMID in a large and contemporary US claims database. Certain pairs of IMIDs co-occur more frequently than others. The risk of developing subsequent IMIDs may be an important consideration for clinicians when selecting treatment strategies.FundingAbbvie.
Publication date: Available online 4 July 2020Source: IDCasesAuthor(s): Nada Al Mahmeed, Wasim El Nekidy, Rumman Langah, Ahmad Rakad Nusair
Serum long noncoding RNAs FAS-AS1 &PVT1 are novel biomarkers for systemic lupus erythematous. Br J Biomed Sci. 2020 Jul 02;:1-5 Authors: Ali MA, Shaker OG, Khalefa AA, Abdelwahed MY, Ali E, Ezzat EM, Elghobary HA, Awaji AA, Fouad NA, Ayoub SE Abstract BACKGROUND: Systemic Lupus Erythematous (SLE) is a chronic systemic autoimmune disorder whose diagnosis depends on combination of multiple factors. Circulating lncRNAs could serve as diagnostic non-invasive biomarkers for SLE. We hypothesised that serum FAS-AS1 and PVT1 are new biomarkers for SLE that relate to clinical features and laboratory markers...
Publication date: September 2020Source: Pharmacological Research, Volume 159Author(s): Paolo Giuffrida, Antonio Di Sabatino
Conclusion: The results of this analysis can serve as a foundation to introduce HRQoL-based recommendations for the use of biologics in the management of IBD in Saudi Arabia. PMID: 32619388 [PubMed - as supplied by publisher]
Authors: DENTAL SUPPLEMENT, Mummolo S, Botticelli G, Quinzi V, Giuca G, Mancini L, Marzo G Abstract Matrix metalloproteases (MMPs) are a family of zinc-dependent endopeptidases, produced by numerous cell types including fibroblasts, endothelial cells, osteoblasts, macrophages, lymphocytes and neutrophils, and capable of degrading different components of the extracellular matrix (ECM), but also cytokines, receptors and factors that regulate cell motility (1). MMPs represent the main proteolytic enzymes involved in the remodeling and degradation of the components of the extracellular matrix, in the modifications of i...
Authors: Fiador F, Poyade M, Bennett L Abstract Arthritis is one of the most common disease states worldwide but is still publicly misunderstood and lacks engaging public awareness materials. Within the UK, the most prevalent types of arthritis are osteoarthritis (OA) and rheumatoid arthritis (RA). The two are commonly mistaken as the same disease but, in fact, have very different pathogenesis, symptoms and treatments. This chapter describes a study which aimed to assess whether an augmented reality (AR) application could be used to raise awareness about the difference between OA and RA.An application was created f...
Authors: Latha S, Selvamani P, Prabha T Abstract Natural products have a unique place in the healthcare industry. The genus Commiphora emerged as a potential medicinal with huge benefits as evidenced through its use in various traditional and modern systems of medicine. Therefore, we aimed to prepare a concise review on the pharmacological activities and the indigenous uses of various plant species belonging to the genus Commiphora along with the structural information of various active botanical ingredients present in these plants based on the published literatures and scientific reports. To collect the various pu...
Conclusion: A significant percentage of patients with SSN have evidence of shoulder double crush syndrome. Patients with SSN and concomitant median neuropathy should have a detailed neck examination performed. PMID: 32612405 [PubMed]
Authors: Mochizuki T, Yano K, Ikari K, Okazaki K Abstract The aim of this study is to identify the factors associated with nutrition in Japanese patients with rheumatoid arthritis (RA). Overall, 409 patients with RA who underwent the Mini Nutritional Assessment (MNA), bone mineral density determination, and body composition assessment by bioelectrical impedance analysis were enrolled. The analysis of factors associated with malnutrition was performed by comparing groups categorized by MNA score (≥24, 17-23.5, and
Conclusion: Isolated renal disease induced by hydralazine as part of drug-induced lupus is uncommon. Our patient developed isolated classic lupus nephritis after hydralazine therapy with no associated systemic vasculitis. Treatment required stopping the hydralazine and initiating systemic immunosuppressive therapy to achieve complete remission. PMID: 32612474 [PubMed]
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