Assessment of the cytotoxic effects of aporphine prototypes on head and neck cancer cells

Conclusion Our results revealed that APO, C1, and A5 exhibit cytotoxic effects in HNSCC cells. The mechanisms of action appear to be partly via the generation of DNA damages and apoptosis induction through Caspase-3 pathway activation. This study provides preclinical data that suggest a potential therapeutic role for APO, C1, and A5 against head and neck cancer cells.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research