Pharmacokinetic Profile of Prolonged-Release Tacrolimus When Administered via Nasogastric Tube in De Novo Liver Transplantation: A Sub-Study of the DIAMOND Trial.

CONCLUSIONS In contrast to previously reported findings in healthy volunteers, nasogastric administration of prolonged--release tacrolimus suspension in liver transplant patients did not substantially affect the PK profile of tacrolimus vs. intact capsules. Nasogastric administration is thus a feasible option to ensure appropriate early tacrolimus exposure in de novo liver transplant recipients. PMID: 31086126 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31086126?dopt=Abstract

Source: Annals of Transplantation - May 13, 2019 Category: Transplant Surgery Authors: Undre N, Baccarani U, Britz R, Popescu I Tags: Ann Transplant Source Type: research