Sex differences and the role of ovarian hormones in site-specific nociception of SHR rats.

Sex differences and the role of ovarian hormones in site-specific nociception of SHR rats. Am J Physiol Regul Integr Comp Physiol. 2019 May 15;: Authors: Maitan Santos B, Nascimento GC, Capel CP, Borges GS, Rosolen T, Sabino JPJ, Leite-Panissi CRA, Branco LGS Abstract The accurate diagnosis and treatment of pain is dependent upon the knowledge of variables that might alter this response. Some of these variables are the locality of the noxious stimulus, the sex of the individual, and the presence of chronic diseases. Among these chronic diseases, hypertension is considered a serious and silent disease that has been associated with hypoalgesia. The main goal of this study was to evaluate the potential nociceptive differences in spontaneously hypertensive rats (SHR) regarding the locality of the stimulus, i.e., the temporomandibular joint or paw, the sex, and the role of ovarian hormones in a model of mechanical nociception (Von Frey test) or formalin-induced inflammatory nociception. Our results indicate that SHR has lower orofacial mechanical nociception beyond the lower mechanical nociception in the paw compared to WKY rats. In a model of formalin-induced inflammatory nociception, SHR also has a decreased nociception compared to normotensive rats. We also sought to evaluate the influence of sex and ovarian hormones on orofacial mechanical nociception in SHR. We observed that female SHR has higher mechanical nociception than male SHR ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - Category: Physiology Authors: Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research