Effects of A Fully Magnetically Levitated Centrifugal-Flow Or Axial-Flow Left Ventricular Assist Device on Von Willebrand Factor: A Prospective Multicenter Clinical Trial

Increased shear stress conferred upon the circulation by continuous flow pumps is associated with hemocompatibility related adverse events, principally bleeding within the gastrointestinal system, and linked to degradation of high molecular weight multimers (HMWM) of von Willebrand factor (vWF). We evaluated the structure and functional characteristics of vWF HMWM in patients with the fully magnetically levitated centrifugal-flow HeartMate 3 (HM3) and the continuous axial-flow HeartMate II (HMII) pump.

Source: The Journal of Heart and Lung Transplantation - May 15, 2019 Category: Transplant Surgery Authors: Aditya Bansal, Nir Uriel, Paolo C. Colombo, Keerthy Narisetty, James W. Long, Arvind Bhimaraj, Joseph C. Cleveland, Daniel J. Goldstein, John Stulak, Samer S. Najjar, David E. Lanfear, Eric D. Adler, Walter Dembitsky, Sami I. Somo, Daniel L. Crandall, Don Tags: Original Clinical Science Source Type: research