Improving haemodynamic optimization of cardiac resynchronization therapy for heart failure
Objective : Optimization of cardiac resynchronization therapy using non-invasive haemodynamic
parameters produces reliable optima when performed at high atrial paced heart rates. Here we
investigate whether this is a result of increased heart rate or atrial pacing itself. Approach :
Forty-three patients with cardiac resynchronization therapy underwent haemodynamic optimization of
atrioventricular (AV) delay using non-invasive beat-to-beat systolic blood pressure in three states:
rest (atrial-sensing, 66 ± 11 bpm), slow atrial pacing (73 ± 12 bpm), and fast atrial pacing
(94 ± 10 bpm). A 20-patient subset underwent a fourth optimization, during exercise (80 ± 11
bpm). Main results : Intraclass correlation coefficient (ICC, quantifying information content
mean ±SE) was 0.20 ± 0.02 for resting sensed optimization, 0.45 ± 0.03 for slow atrial pacing (
p
Source: Physiological Measurement - Category: Physiology Authors: Alexander J Sharp, S M Afzal Sohaib, Matthew J Shun-Shin, Punam Pabari, Keith Willson, Christopher Rajkumar, Alun D Hughes, Prapa Kanagaratnam, Jamil Mayet, Zachary I Whinnett, Andreas A Kyriacou and Darrel P Francis Source Type: research
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