Insight into the Selective Binding Mechanism of DNMT1 and DNMT3A Inhibitors: A Molecular Simulation Study

Phys. Chem. Chem. Phys., 2019, Accepted Manuscript DOI: 10.1039/C9CP02024A, PaperTianli Xie, Jie Yu, Weitao Fu, Zhe Wang, Lei Xu, Shan Chang, Ercheng Wang, Su Zeng, Feng Zhu, Yu Kang, Tingjun Hou DNA methyltransferases (DNMTs), responsible for regulation of DNA methylation, have been regarded as promising drug targets for cancer therapy. However, high structural conservation of the catalytic domains of DNMTs poses... The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Phys. Chem. Chem. Phys. latest articles - May 17, 2019 Category: Chemistry Authors: Tianli Xie Source Type: research