The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress [Signal Transduction]

In conclusion, our results indicate that TM-induced UPR activates functional autophagy, and whereas IRE1 is a negative regulator, PERK and ATF4 are required at distinct steps in the autophagic pathway.

Source: Journal of Biological Chemistry - May 16, 2019 Category: Chemistry Authors: Morten Luhr, Maria Lyngaas Torgersen, Paula Szalai, Adnan Hashim, Andreas Brech, Judith Staerk, Nikolai Engedal Tags: Cell Biology Source Type: research