Electron diffraction determines molecular absolute configuration in a pharmaceutical nanocrystal

We present a complete structure analysis of a pharmaceutical cocrystal of sofosbuvir and l-proline, which is about one order of magnitude less stable. Data collection on multiple positions of a crystal and an advanced-intensity extraction procedure enabled us to solve the structure ab initio. We further show that dynamical diffraction effects are strong enough to permit unambiguous determination of the absolute structure of material composed of light scatterers.
Source: ScienceNOW - Category: Science Authors: Tags: Materials Science, Techniques reports Source Type: news