Screening sarcoidosis patients for cardiac sarcoidosis: What the data really show
Cardiac sarcoidosis is a major cause of death in sarcoidosis patients. In most series, cardiac sarcoidosis is second only to pulmonary sarcoidosis in causes of death related to sarcoidosis , although cardiac sarcoidosis has been found to be the leading cause of death in some reports [2,3]. More importantly, the deaths from cardiac sarcoidosis may occur suddenly and early after diagnosis, relating to the development of a small focus of granulomatous inflammation in a strategically vulnerable portion of the cardiac conduction system.
ConclusionsAccording to our results in a clinical setting of recurrent or residual lymphoma, FLT is not significantly superior to FDG and it is unlikely that it will be employed independently. FLT may be restricted to a few specific cases, as complementary to standard FDG imaging, to confirm a diagnosis or to define a better target to biopsy. However, due to FLT suboptimal performance, many findings would remain inconclusive, requiring further diagnostic procedures and reducing the effectiveness of performing an additional FLT scan.
This article presents an oncologic patient with oropharyngeal cancer. After surgery with bilateral neck dissection and adjuvant radiation, the patient developed foreign body granuloma in the area of neck dissection in addition to cervical and mediastinal granuloma. Possible differential diagnoses in this situation are sarcoidosis or tumor-derived sarcoid-like lesions, but also metastases. Therefore, intensified follow-up is particularly important for oncologic patients developing granulomas. PMID: 31187149 [PubMed - as supplied by publisher]
AbstractPulse oximetry is an important diagnostic tool in monitoring and treating both in-patients and ambulatory patients. Modern pulse oximeters exploit different body sites (eg fingertip, forehead or earlobe). All those are bulky and uncomfortable, resulting in low patient compliance. Therefore, we evaluated the accuracy and precision of a wrist-sensor pulse oximeter (Oxitone-1000, Oxitone Medical) vs. the traditional fingertip device. Fifteen healthy volunteers and 23 patients were recruited. The patient group included chronic obstructive pulmonary disease (COPD) (N = 8), asthma (N = 6), sar...
Publication date: July 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 128, Issue 1Author(s): Dr. Ronald Faram, Dr. Paul Freedman, Dr. Renee ReichChronic granulomatous inflammatory reactions are uncommon in the oral cavity. These lesions are reactive in origin and are characterized by macrophages which fuse to form multinucleated giant cells or transform into epithelioid histiocytes. Multiple etiologies exist for CGIR and include foreign body reactions to endogenous and exogenous materials, allergic reactions, infectious diseases (fungal or bacterial), sarcoidosis, and Crohn's disease. He...
ConclusionOur preliminary data suggest that, compared to FDG imaging, somatostatin receptor-targeted imaging may be less sensitive for the detection of myocardial inflammation, but comparable for detecting extra-cardiac inflammation.
The clinical phenomenon of a spontaneous disappearance of an enhancing lesion on cerebral computed tomography (CCT) or magnetic resonance imaging with gadolinium (MRI) is referred to as a vanishing tumor . This is a phenomenon observed in 1:60.000 –1:100.000 cancer patients.  The differential diagnoses include primary central nervous system lymphoma (PCNSL), demyelinating disease, glioma with spontaneous regression, inflammatory disease, such as sarcoidosis, Behcets disease/angiitis with granoulomatosis and parasitic disease.
ConclusionSUVmax and TLuG are equal in determining the response to infliximab in pulmonary sarcoidosis patients. Furthermore, SUVmax and TLuG at initiation of infliximab can predict change in lung function after treatment. Since TLuG is a more time-consuming tool, we recommend to use SUVmax of the lung parenchyma for response monitoring in pulmonary sarcoidosis.
AbstractThe disease burden, risk factors and clinical sequelae of CMV reactivation in patients with rheumatologic conditions is poorly understood. We have described a cohort with underlying rheumatic disease and CMV, and compared a subgroup with systemic lupus erythematosus (SLE) to controls to identify potential risk factors for CMV reactivation. Adults with rheumatic disease and CMV infection from 2000 –2015 were identified. SLE cases were matched 3:1 with controls based on age, sex and year of admission, and compared. Fourteen patients were included (6 SLE, 4 rheumatoid arthritis, 2 sarcoidosis, 1 psoriatic arthri...
ConclusionGeoepidemiological research should focus on evaluating the combined effects of environmental and genetic factors, the identification of clusters of geographically driven exposures, and more precise measurement of all personal exposures (degree of combination, length, and level of exposure).