Orbital Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Masquerading as Pleomorphic Lipoma: A Diagnostic Challenge

Atypical lipomatous tumor/well-differentiated liposarcoma is a common neoplasm of the superficial and deep soft tissues of the extremities, trunk, and retroperitoneum. Atypical lipomatous tumor/well-differentiated liposarcoma is very rare in the orbit, with only 19 previously reported cases. The authors describe a 22-year-old woman who presented with an 8-month history of diplopia and was found to have an orbital mass on MRI. The excised tumor initially was interpreted as spindle cell/pleomorphic lipoma based on its morphologic and immunohistochemical features. Nine years later, the patient returned with a recurrence that required surgical debulking. Histopathologic and molecular cytogenetic evaluation of both primary and recurrent lesions disclosed Atypical lipomatous tumor/well-differentiated liposarcoma. This case highlights the diagnostic challenges and the importance of molecular genetic studies in evaluation of fatty orbital tumors.
Source: Ophthalmic Plastic and Reconstructive Surgery - Category: Opthalmology Tags: Case Reports Source Type: research

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DiscussionThe prevalence of adipose tumors is underestimated within hand and wrist tumors. The most common way these tumors are discovered is due to compressive neuropathy with paresthesia and/or dysesthesia. While these tumors are nearly always benign, this does not justify ignoring the opinion of the multidisciplinary tumor board or underestimating the small possibility of the lesion being a liposarcoma.Level of evidenceIV, retrospective, single-center study.
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
CONCLUSION: Liver nodules should be characterised with regard to underlying liver condition, MRI characteristics and contrast enhancement pattern, including hepatobiliary phase. In many cases, identification of fatty content may help narrowing the differential diagnosis. PMID: 32008550 [PubMed - in process]
Source: Current Medical Imaging Reviews - Category: Radiology Tags: Curr Med Imaging Rev Source Type: research
Authors: Malinauskaite I, Hofmeister J, Burgermeister S, Neroladaki A, Hamard M, Montet X, Boudabbous S Abstract Distinguishing lipoma from liposarcoma is challenging on conventional MRI examination. In case of uncertain diagnosis following MRI, further invasive procedure (percutaneous biopsy or surgery) is often required to allow for diagnosis based on histopathological examination. Radiomics and machine learning allow for several types of pathologies encountered on radiological images to be automatically and reliably distinguished. The aim of the study was to assess the contribution of radiomics and machine learn...
Source: Sarcoma - Category: Cancer & Oncology Tags: Sarcoma Source Type: research
Rationale: Oral liposarcoma is an extremely rare lesion that is often clinically misdiagnosed as a benign lesion because of its asymptomatic and indolent clinical course. we report a case of atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) of buccal mucosa, provisionally diagnosed as lipoma. Patient concerns A 97-year-old female was referred to dentistry and oral surgery department with an asymptomatic mass on the right buccal mucosa which had been present for an unknown period of time. Diagnosis Magnetic resonance imaging demonstrated a well-circumscribed lesion at the right buccal mucosa, and a...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Publication date: June 2020Source: Interdisciplinary Neurosurgery, Volume 20Author(s): Hemant Sah, Dipendra Kumar Shrestha, Binod Rajbhandari, Amit Bahadur Pradhnang, Sushil Krishna ShilpakarAbstractSpindle cell lipomas (SCL) are rare, slow-growing and benign fatty neoplasms, which are commonly located in the subcutaneous layer of the posterior neck and upper back. Due to the similarities in the clinicoradiological features, it needs to be differentiated from other benign and malignant soft tissue tumors including liposarcoma. Preoperative diagnosis is usually difficult; and, hence, a histopathological study is required to...
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
ConclusionAlthough ossifying lipomas are very rare, it is important to keep them in mind when a lesion with adipose tissue in combination with ossification is encountered.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
We present a case of a 57-year-old white female with a left upper thigh mass located at the previous surgical site of the resection of a 15 cm, 505-glipoma 10 years ago. Magnetic resonance imaging showed a 1.7 × 3.1 × 2.9 cm soft tissue mass within the subcutaneous adipose tissues of her left upper thigh at the site of previous lipoma resection. No muscle or bone invasion was identified. The clinical impression was lipoma versus liposarcoma. The mass was surgically removed, and gross examination showed a tan-pink, well-demarcated soft mass with scalloped edges noted within the...
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research
CONCLUSION: Radiomics is a promising, non-invasive method for differentiating between WDLPS and lipoma, outperforming the scores of the radiologists. Further optimization and validation is needed before introduction into clinical practice. PMID: 31747074 [PubMed - in process]
Source: The British Journal of Surgery - Category: Surgery Authors: Tags: Br J Surg Source Type: research
CONCLUSIONS: Currently, there is no evidence-based recommendation available regarding the management of lipomas detected during open or laparoscopic inguinal hernia surgery. Due to the extremely low risk of the presence of a liposarcoma routine histologic examination cannot be recommended unless the diameter exceeds 10 cm. PMID: 31690184 [PubMed - as supplied by publisher]
Source: Acta Chirurgica Belgica - Category: Surgery Tags: Acta Chir Belg Source Type: research
ConclusionsThere is a significant relationship between a radiomics signature, consisting of a combination of quantitative MRI features, and the MDM2-amplification status. Although further optimization and validation is needed for the transition to clinical practice, radiomics has appeared to be a promising, non-invasive approach for the classification of WDLPS and lipomas.AcknowledgementM.Vos and M.P.A. Starmans contributed equally to this study.Legal entity responsible for the studyThe authors.FundingStichting Coolsingel, Netherlands Organisation for Scientific Research, Dutch Cancer Society.DisclosureAll authors have dec...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
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