Effect of a background Ca2+ entry pathway mediated by TRPC1 on myocardial damage of broilers with induced ascites syndrome.

Effect of a background Ca2+ entry pathway mediated by TRPC1 on myocardial damage of broilers with induced ascites syndrome. Avian Pathol. 2019 May 14;:1-26 Authors: Qiao N, Pan J, Kang Z, Liu G, Tang Z, Li Y Abstract Ascites syndrome (AS) in chickens is associated with profound vascular remodeling and increased pulmonary artery pressure as well as right ventricular hypertrophy. Classical transient receptor potential cation channels (TRPCs) are key regulators of cardiac hypertrophy that act via regulation of calcium influx in mammals. We investigated whether classical transient receptor potential channels in chickens with right ventricular hypertrophy still possess this mechanism for regulating Ca2+ flux. Intravenous injection of cellulose particles was successfully used to induce AS in chickens and tissues were examined 22 days after treatment. These chickens in test group showed cardiac hypertrophy with edema of the cardiac muscle and disruption of myofilaments. The right-to-total ventricle weight ratio (RV/TV), the levels of serum aspartate aminotransferase (AST) and the creatine kinase (CK) of the test group were significantly higher than the control group. Intracellular calcium levels were significantly increased in cardiomyocytes from chickens in test group. Gene expression of TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 in heart tissues from test group showed no significant differences with controls. However, TRPC1 protein levels as well as mRNA levels wer...
Source: Avian Pathology - Category: Pathology Authors: Tags: Avian Pathol Source Type: research

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In this study, we detected for just the second time a SINV infection in a diseased wild bird (common wood pigeon) from Central Europe. SINV was isolated by cell culture and the complete SINV genome sequence was determined. Phylogenetic analyses revealed a close affiliation to SINV genotype I with a high similarity to human isolate sequences from Finland, Sweden and Russia. The isolate was genetically distinct from the first avian isolate suggesting the circulation of at least two different SINV strains in Germany.In order to reveal the infection frequency in SINV positive mosquito regions 749 bird blood samples were assaye...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
A recent study in this journal compared codon usage among NA subtypes (N1, N2, N6, and N8)  of H5Nx highly pathogenic avian influenza A viruses (HPAIVs) and suggested that codon usage in N1 subtype is better adapted to its host than the epidemic NA subtypes (N6 and N8), which had fewer number of human cases compared to the N1 subtype.1 To date, there are 18 known HA subtypes (H1-H18) and 11 known NA subtypes (N1-N11)2. However, only N1 and N2 subtypes have been reported to cause pandemics (H1N1 for the 1918 and 2009 pandemics; H2N2 for the 1957 pandemic; and H3N2 for the 1968 pandemic) or seasonal outbreaks in humans3.
Source: Journal of Infection - Category: Infectious Diseases Authors: Tags: Letter to the Editor Source Type: research
Campylobacter jejuni (C. jejuni) are able to colonise and infect domestic poultry and also pose a risk for humans. The aim of this study was to determine the extent of genotypic diversity among C. jejuni isolates recovered from avian and human sources in Egypt. Furthermore, the short variable region (SVR) of flagellin A (flaA) gene was analysed for the presence of allelic variants. Our results showed that C. jejuni isolates differ in their capacity to harbour each of the virulence genes alone or when present in various combinations. The flaA gene was detected in all C. jejuni strains and none of the strains had all the stu...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
K. E. Lafond et al.
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
Abstract Avian pathogens such as bornaviruses, circoviruses and polyomaviruses are widely distributed in captive collections of psittacine birds worldwide and can cause fatal diseases. In contrast, only little is known about their presence in free-ranging psittacines and their impact on these populations. Rose-ringed parakeet (Psittacula krameri) and Alexandrine parakeets (Psittacula eupatria) are non-native to Europe, but have established stable populations in parts of Western Europe. During 2012 to 2017, we surveyed free-ranging populations in Germany and France as well as captive Psittacula individuals from Ger...
Source: Avian Pathology - Category: Pathology Authors: Tags: Avian Pathol Source Type: research
This study suggests that photodynamic treatment can be used to manufacture “bald” virions for experimental purposes. Photodynamic inactivation is based on the production of reactive oxygen species which attack and destroy biomolecules. Thus, the results of this study can potentially apply to other enveloped viruses and sources of singlet oxygen.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
High Altitude Medicine&Biology, Ahead of Print.
Source: High Altitude Medicine and Biology - Category: Sports Medicine Authors: Source Type: research
In this study, we showed that expression of the cellular miRNA gga-miR-455-5p was downregulated in vivo and in vitro in response to NDV infection. Next, we found that the transfection of chicken embryonic fibroblasts (CEFs) with gga-miR-455-5p suppressed NDV replication, while the blockade of endogenous gga-miR-455-5p expression with inhibitors enhanced NDV replication. In addition, gga-miR-455-5p enhanced the expression of type I interferon and the interferon-inducible genes (ISGs) OASL and Mx1 by targeting SOCS3, a negative regulator of type I IFN signaling. Altogether, these findings highlight the crucial role of gga-mi...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Cryopreservation of avian species Pure heritage breed broiler chicken reconstituted from frozen genetic material surrounded by brown layer offspring. Image courtesy of Norman Russell (University of Edinburgh, Edinburgh, United Kingdom). The high lipid content of some avian eggs renders it challenging to preserve genetic material from rare or endangered species...
Source: Proceedings of the National Academy of Sciences - Category: Science Tags: In This Issue This Week in PNAS Source Type: research
H, Heylen D Abstract Wild birds are frequently exposed to the zoonotic tick-borne bacteria Borrelia burgdorferi sensu lato (s.l.), and some bird species act as reservoirs for some Borrelia genospecies. Studying the tropism of Borrelia in the host, how it is sequestered in different organs, and whether it is maintained in circulation and/or in the host's skin is important to understand pathogenicity, infectivity to vector ticks and reservoir competency.We evaluated tissue dissemination of Borrelia in blackbirds (Turdus merula) and great tits (Parus major), naturally and experimentally infected with Borrelia genospe...
Source: Microbial Ecology - Category: Microbiology Authors: Tags: Microb Ecol Source Type: research
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