Multiple airborne allergen-induced eosinophilic chronic rhinosinusitis murine model

ConclusionsWe successfully established a new murine model of ECRS using more clinically relevant multiple airborne allergens. Prolonged exposure to airborne allergens for 12  weeks or more, corresponding to the definition of human ECRS, strongly induced eosinophil infiltration as well as epithelial remodeling.
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research

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In this study, chemically pretreated SB was mixed with dry spent yeast (DSY) at a mass ratio of 60:40 before being fermented under solid-state fermentation (SSF) by Aspergillus niger TK1. The fermented solids at a concentration of 24 g/L (on a dry basis) was subsequently hydrolyzed to produce a hydrolysate, which was concentrated to contain 29.7 ± 0.6 g/L of reducing sugar and 585.1 ± 6.5 mg/L of free amino nitrogen. The concentrated hydrolysate was fermented by Saccharomyces cerevisiae TISTR 5339, yielding 8.98 ± 0.2 g/L of ethanol....
Source: Biochemical Engineering Journal - Category: Biochemistry Source Type: research
CONCLUSION: Early, appropriate estimation of sinonasal conditions appears to be crucial for successful surgical management of chronic rhinosinusitis. PMID: 31218991 [PubMed - as supplied by publisher]
Source: Journal of Laryngology and Otology - Category: ENT & OMF Tags: J Laryngol Otol Source Type: research
ConclusionColonoscopy with right-sided retroflexion after forward-view examination significantly increases the detection of adenomas compared with standard forward-view examination with a high success rate and small risk of adverse events.ResumoAntecedentes e objetivoOs adenomas do cólon direito podem não ser diagnosticados, apresentando uma elevada taxa de não detecção de adenoma, especialmente quando estão localizados atrás das pregas haustrais e flexões anatômicas. O objetivo deste estudo foi comparar, no cólon direito, a técnica de visualiza&cc...
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
We describe three cases of breakthrough pneumococcal severe life-threatening infections, including two meningitis and one bloodstream infection in patients treated with cefixime for otitis, sinusitis and pneumonia, respectively. Cefixime does not seem to be fully effective in treating invasive pneumococcal diseases. Because penicillin non-susceptibility might be linked to cefixime failure, the prompt knowledge of susceptibility to penicillin in S. pneumoniae might be very useful. Furthermore, MIC of cefixime should be measured because values>0.5 mg/L might be related to failure. PMID: 31215358 [PubMed - as supplied by publisher]
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
CONCLUSIONS: There is a high frequency of IFs, yet not all of them require immediate medical attention. The low prevalence of threatening IFs emphasizes that CBCT should not be considered a substitution for conventional radiographs, but when used, the scans should be evaluated by a maxillofacial radiologist. PMID: 31216179 [PubMed - as supplied by publisher]
Source: Dentomaxillofacial Radiology - Category: Radiology Tags: Dentomaxillofac Radiol Source Type: research
Conclusions The major outcome of this review is that AC showed essentially no effect in human studies, whereas AC-enriched diets proved to be effective in experimental murine models of CRC. In cell culture tests, AC showed to interfere with cell signaling pathways related to cell growth and differentiation, apoptosis, oxygen stress and inflammation response. Further molecular characterisations are required to include AC is the panel of disease-modifying agents.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
We present the case of a 43-year-old female diagnosed with a pancreatobiliary maljunction and an associated stenosis of the bile duct, secondary to an episode of acute pancreatitis. She underwent several endoscopic retrograde cholangiopancreatography procedures over the course of three years, without improvement of the stenosis, and therefore a surgical approach was taken. Prior to the surgical intervention, magnetic resonance imaging showed the presence of an 11-mm polyp in the gallbladder. A histological study of the surgical sample identified intramucosal adenocarcinoma over a tubular adenoma of the gallbladder. Pancrea...
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
Publication date: Available online 15 June 2019Source: Journal of Molecular LiquidsAuthor(s): Ahmad Desoky M. Mohamad, M.J.A. Abualreish, Ahmed M. Abu-DiefAbstractThe present study focused on the measurement of the solubilities and the calculation of the chemical potentials of transfer of Co(III)-hydrazone complexes in mixtures of water and ethyl alcohol (EtOH), isopropyl alcohol (i-PrOH), or tert-butyl alcohol (t-BuOH) at 298 K, using the assumption that δm μθ Ph4As+ = δm μθ BPh4− (TATB). A comparison between the chemical potentials of transfer of Co(III)-hydrazone complex ions wi...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
It ’s not unusual for patients in their 20s and 30s to visit WellNow Urgent Care, especially for minor injuries or illness. Whether it’s sinusitis, repetitive-use injuries from computers or recreational sports-related sprains, millennials have grown up with the urgent care option so that’s become the norm when they need to see a doctor. While millennials account for 23 percent of patients at WellNow’s 11 sites in Western New York, individuals in the 18-34 age range make up 34 percent of…
Source: bizjournals.com Health Care News Headlines - Category: Health Management Authors: Source Type: news
This study was supported by grants from GSK and the UK Medical Research Council (U105178805). Conflict of Interest Statement AM has grant funding from GSK and AstraZeneca/MedImmune. MB, DJ, AP, DT, and AvO are employees of GSK. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We are grateful to the Ares staff, genotyping facility, and flow cytometry core for their technical assistance. We thank Jen Walker for advice on the manuscript. Supplementary Material The Supplem...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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