Efficacy and safety of fractionated conformal radiation therapy in acromegaly: a long-term follow-up study

AbstractBackground and purposeConformal, fractionated radiation therapy (XRT) is variably used as a treatment alternative for active acromegaly patients, usually, after failed pituitary surgery. Our objective was to evaluate the long-term efficacy and safety of XRT using strict criteria of biochemical control.Setting, design, patients, and methodsRetrospective cohort study of 94 patients (73 women, mean age at radiation 53.16  ± 12.9 years) attending a specialized multidisciplinary clinic between 1998 and 2014 with a mean duration of follow-up of 12.9 ± 7.3 years.ResultsA basal growth hormone
Source: Endocrine - Category: Endocrinology Source Type: research

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In this study, analysis of antioxidant defense was performed on the blood samples from 184 "aged" individuals aged 65-90+ years, and compared to the blood samples of 37 individuals just about at the beginning of aging, aged 55-59 years. Statistically significant decreases of Zn,Cu-superoxide dismutase (SOD-1), catalase (CAT), and glutathione peroxidase (GSH-Px) activities were observed in elderly people in comparison with the control group. Moreover, an inverse correlation between the activities of SOD-1, CAT, and GSH-Px and the age of the examined persons was found. No age-related changes in glutathione reductas...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusions: This is a large study of the molecular genetics of CHH providing new genetic findings for this complex and heterogeneous genetic condition. NGS has been shown to be a fast, reliable and effective tool in the molecular diagnosis of congenital CHH and being able to targeting clinical genetic testing in the future. PMID: 31200363 [PubMed - in process]
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Tags: Eur J Endocrinol Source Type: research
AbstractPurposeTo report the dosimetric feasibility of the radiation technique HALFMOON (Helical ALtered Fractionation for iMplant partial OmissiON) for post-mastectomy radiation therapy (PMRT) in intermediate –high-risk breast cancer patients with implant-based immediate breast reconstruction, where the clinical target volume (CTV) does not include the whole implant (implant-sparing approach).MethodsIn the HALFMOON technique, the CTV consisted of skin, subcutaneous tissues, and pectoralis major muscle, excluding the implant, chest wall muscles, and rib plane. The HALFMOON plans were compared with conventionally cont...
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Abstract Pain is common among patients with head and neck cancer (HNC). However, there are very limited data on chronic pain among HNC patients treated with radiation therapy (XRT). In this retrospective study, we focused on the characteristics of chronic post-XRT pain in such patients. Post-XRT pain is common among HNC patients; however, we found discrepancy between frequency of treatment and frequency of chronic pain, suggesting poor documentation of pain in the medical records. Among patients who reported to have chronic post-XRT pain, most of them described having severe pain and used descriptors of neuropathi...
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
Authors: Hozumi K, Fukuoka H, Odake Y, Takeuchi T, Uehara T, Sato T, Inoshita N, Yoshida K, Matsumoto R, Bando H, Hirota Y, Iguchi G, Taniguchi M, Otsuki N, Nishigori C, Kosaki K, Hasegawa T, Ogawa W, Takahashi Y Abstract Although acromegaly has been reported in patients with Neurofibromatosis type 1 (NF1), these cases have not been associated with growth hormone (GH)-producing somatotroph adenoma, but with optic pathway glioma. A 68 year-old Japanese woman, who had been clinically diagnosed with NF1, was referred to our hospital due to a thyroid tumor and hypercalcemia. Acromegaly was suspected due to her facial f...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
In the current issue, Dr Roach and colleagues1 analyze regional and national insurance policies for stereotactic body radiation therapy (SBRT). They investigate the recent evolution of coverage for various clinical indications in relation to the indications that the American Society for Radiation Oncology's (ASTRO's) SBRT Model Policy recommends for coverage. The authors observe a trend toward higher concordance between ASTRO's recommendations and those accepted by payers as conditions of medical necessity for SBRT, although some discrepancies remain.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Payment Policy Source Type: research
Let's get to the punchline because it is a big one: Radiation therapy plus cetuximab led to inferior overall survival (OS) in human papilloma virus (HPV)-positive oropharyngeal squamous cell carcinoma (SCC). It is in light of the recently published results from Radiation Therapy Oncology Group (RTOG) 1016 and De-ESCALaTE HPV that we scope this issue's Oncology Scan to discuss the populist view that has prevailed among the head and neck cancer community for some time now: treatment de-intensification in HPV-positive oropharyngeal SCC (OPSCC).
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Feature Source Type: research
At the conclusion of a recent office visit, one of our patients summarized his feelings and stated, with a sense of absolute conviction, “The only type of radiation therapy I am willing to undergo is proton therapy.” In contrast, another recent patient facing a similar situation stated, “I don't care which I get [proton or photon therapy]; to me, it sounds like it's the team, not the beam.” The former patient put his hope in a technology; the latter patient prioritized the experience of his care team over any particular technology.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Payment Policy Source Type: research
There has been no recent randomized evidence justifying postoperative radiation therapy (PORT) in patients with non-small cell lung cancer who have undergone complete resection; it is not recommended for routine use, even in patients with mediastinal involvement (pN2).1,2 Adjuvant treatments such as chemotherapy and PORT should be discussed at a multidisciplinary board with complete surgical and pathologic reports, checking whether the nodal exploration was appropriate, the location and number of mediastinal nodes and hilar/intrapulmonary nodes that were resected, and whether resection was complete.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
ConclusionsIn experienced hands, transsphenoidal microsurgery for PAs achieves remission in most patients with a low complication rate. Pituitary function is preserved in most cases and can recover in more than one-third of patients with preoperative hypopituitarism.
Source: Endocrine - Category: Endocrinology Source Type: research
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