MicroRNA-664 functions as an oncogene in cutaneous squamous cell carcinomas (cSCC) via suppressing interferon regulatory factor 2

Epidermal keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the second most common cancer with over one million new cases annually worldwide [1 –4]. Chronic exposure to sunlight ultraviolet (UV) radiation is a major risk factor for skin cancer such as cSCC [5,6]. cSCC is also associated with a substantial risk of metastasis, contributing to approximately 20% of skin cancer-related deaths [7,8]. Nonetheless, metastatic or locally advanced cSCC patients are not applicable for surgical or radiotherapy strategies.

Source: Journal of Dermatological Science - May 15, 2019 Category: Dermatology Authors: Xiangzhi Li, Cheng Zhou, Chen Zhang, Xiongxiong Xie, Zhaoming Zhou, Meijuan Zhou, Longhua Chen, Zhenhua Ding Source Type: research