Initial real-world experience with PCSK-9 inhibitors in current indications for reimbursement in Spain

Publication date: Available online 16 May 2019Source: Revista Española de Cardiología (English Edition)Author(s): Alberto Cordero, Lorenzo Fácila, Moisés Rodríguez-Mañero, Manuel J. Gómez-Martínez, Vicente Bertomeu-Martínez, Jose R. González-Juanatey
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research

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Publication date: Available online 20 July 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Jin Geun Kwon, Young Jun Choi, Sung Chan Kim, Joon Pio Jp Hong, Woo Shik Jeong, Tae Suk OhAbstractDuring deep tissue dissection in the face, it is sometimes difficult to distinguish the facial nerve from surrounding tissue, leading to a risk of facial nerve injury. To identify the facial nerve during such procedures, we used a fluorescence-assisted near-infrared camera. Indocyanine green (ICG)-assisted direct visualization was used intraoperatively in 13 cases. The procedures included excision of neurofibromas (n=10) an...
Source: Journal of Cranio Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: Available online 25 June 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Quentin Hennocq, Amin Bennedjaï, François Simon, Sylvie Testelin, Bernard Devauchelle, Jean-François Tulasne, Stéphanie Dakpé, Roman Hossein KhonsariAbstractThe Iraq–Iran war (1980–88) resulted in numerous maxillofacial injuries. More than 400,000 people were wounded and required specialist care. Paul Tessier, a leading French plastic surgeon and pioneering craniofacial surgeon, was involved in several missions to Iran and operated on a vast cohort of patients with complex wa...
Source: Journal of Cranio Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: Available online 20 July 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Z. Yang, Q. Liang, K. Ouyang, Z. Piao
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
ConclusionPositron emission computed tomography is useful for the diagnosis of head and neck squamous cell carcinoma, improving the patient's staging especially when detecting cervical and distant metastases. Therefore, we consider that the use of positron emission computed tomography for the staging of patients with head and neck squamous cell carcinoma is a diagnostic test to be considered.ResumoIntroduçãoO carcinoma espinocelular de cabeça e pescoço é o sétimo tumor maligno mais comum. Os avanços no tratamento melhoraram as taxas de sobrevida global nos últimos ano...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
Publication date: Available online 20 July 2019Source: Pharmacological ResearchAuthor(s): Jiasi Wu, Yu Luo, Qing Jiang, Sheng Li, Wenge Huang, Li Xiang, Deming Liu, Yingfan Hu, Ping Wang, Xiaoxia Lu, Guolin Zhang, Fei Wang, Xianli MengAbstractInflammasome mediates the activation of caspase-1, which promotes the secretion of proinflammatory cytokines. In this work, we aimed to investigate whether natural compounds from a Traditional Chinese Medicine prescription called San-Huang-Xie-Xin-Tang exert its clinical efficacy by inhibiting inflammasome activation and the underlying mechanism. The inhibitory effects of compounds on...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
This study would contribute to a better understanding of pedunculoside metabolism, which can provide scientific evidence for its pharmacodynamic mechanism research and prove its clinical application.Graphical abstract
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
ConclusionThese results clearly demonstrated the lignans from Schisandra sphenanthera exert hepatoprotective effects against LCA-induced cholestasis by activation of PXR. These lignans may provide an effective approach for the prevention and treatment of cholestatic liver injury.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
This study included 20 pharmaceutical materials, and each material was characterized by 44 properties, capturing 880 data points. The stress conditions of a commonly used feeder hopper were calculated using the Janssen model for six selected materials. Multivariate analysis, such as principal component analysis and clustering analysis, was used to explore the knowledge space of the material library. Statistically similar and dissimilar material properties were evaluated for material feeding performance from a loss-in-weight feeder to test utility of the material library. 20 materials included in this study show a wide rang...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 20 July 2019Source: International Journal of PharmaceuticsAuthor(s): Marcilio Cunha-Filho, Maíra T. Teixeira, Víctor Santos-Rosales, Livia L. Sa-Barreto, Ricardo N. Marreto, Manuel Martin-Pastor, Carlos A. García-González, Mariana LandinAbstractThe subdivision behavior of polymeric tablets produced with the well-known polymers Soluplus® (SOL), polyvinyl pyrrolidone co-vinyl acetate (PVPVA) and hydroxypropyl methylcellulose (HPMC) was evaluated in this study. The polymeric tablets were submitted to different post-treatments (aging, thermal and exposure to co...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 20 July 2019Source: International Journal of PharmaceuticsAuthor(s): Michael B. Lowinger, James Ormes, Yongchao Su, James H. Small, Robert O. Williams, Feng ZhangAbstractImplants offer the opportunity to improve patient adherence and real-world outcomes. However, most polymers used today are hydrophobic and limit drug properties suitable for development. Thermoplastic poly(urethanes) (TPUs) form pores upon hydration and may facilitate the development of implants containing drugs exhibiting broadly different properties. We sought to investigate the effect of drug physicochemical properties...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
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