Current results and remaining challenges of trans-catheter aortic valve replacement expansion in intermediate and low risk patients

Publication date: June 2019Source: IJC Heart &Vasculature, Volume 23Author(s): Alfonso Ielasi, Azeem Latib, Maurizio Tespili, Francesco DonatelliAbstractTAVR has become the standard treatment in patients at increased surgical risk (STS or EuroSCORE II ≥4% or logistic EuroSCORE I ≥ 10% or other risk factors not included in these scores such as frailty, porcelain aorta, sequelae of chest radiation) and it is increasingly being performed in patients at intermediate to low (STS or EuroSCORE II
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research

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The transcatheter aortic valve replacement market received one of the biggest jolts of the year when FDA expanded indications of both Edwards Lifesciences and Medtronic’s valves. FDA’s measure would open up the valves to be used in younger and low-risk patients. The agency said these transcatheter valves – Edwards’ Sapien 3, and Sapien 3 Ultra, with Medtronic’s CoreValve Evolut R and CoreValve Evolut PRO – were previously indicated only for patients at intermediate or higher risk for death or major complications duri...
Source: MDDI - Category: Medical Devices Authors: Tags: Cardiovascular Regulatory and Compliance Source Type: news
ConclusionsAll 3 scoring systems can be applied to Chinese population with excellent risk prediction. QMH risk score has a role in accurately predicting mortality rates in Hong Kong population.This article is protected by copyright. All rights reserved.
Source: Surgical Practice - Category: Surgery Authors: Tags: Original Article Source Type: research
Transcatheter mitral valve implantation for degenerated bioprostheses has recently emerged as an alternative to redo mitral valve surgery, particularly in patients at high risk for reoperative cardiac surgery. We sought to examine our early experience of transcatheter transseptal mitral valve-in-valve procedures.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: Original Article Source Type: research
Transcatheter aortic valve replacement (TAVR) has inexorably altered the way physicians are able to treat symptomatic severe aortic stenosis.1 Patients once deemed too high-risk for surgical valve replacement (SAVR) are now able to undergo a percutaneous procedure for aortic stenosis treatment. Through large-scale multi-center trials, TAVR has been shown to be safe across all risk profiles, including low risk, expanding TAVR as a viable option to SAVR.2,3 Refinements in pre-procedural planning, extensive experience in peri- and intra-procedural imaging, as well as continual valve design innovation have further improved cli...
Source: Journal of Cardiovascular Computed Tomography - Category: Radiology Authors: Tags: Editorial Source Type: research
Publication date: Available online 17 August 2019Source: IDCasesAuthor(s): Mohamadreza Salehi, Sahar Shadvar, Mohammad Sadeghian, Mahsa Doomanlou, Alireza Abdollahi, Seyed Ali Dehghan Manshadi, Akram Sardari, Hossein Ali Rahdar, Mohammad Mehdi FeizabadiAbstractAeromonas salmonicida (A. salmonicida) is a facultative Gram-negative bacillus, inhabiting in water. It is a common source of furunculosis and septicemia in fish. Report on the human infection with this organism is rare. A male farmer referred with weakness and intermittent fever. He had cardiac valves’ regurgitation due to fever with rheumatic heart disease. H...
Source: IDCases - Category: Infectious Diseases Source Type: research
Authors: Seeger J, Romero M, Schuh C, Virmani R, Wöhrle J Abstract BACKGROUND: Use of the dual-filter cerebral embolic protection (CEP) device has been linked to a lower stroke rate in patients undergoing transfemoral transcatheter aortic valve replacement (TAVR). Captured debris is found in almost every filter. The impact of repositioning on number and area of captured debris has not been studied. METHODS: Consecutive patients (n = 200) undergoing transfemoral TAVR with double-filter CEP device were included. A total of 400 filters were analyzed. Histopathologic assessment and histomorphometric analyses o...
Source: The Journal of Invasive Cardiology - Category: Cardiology Tags: J Invasive Cardiol Source Type: research
CONCLUSION: TF-TAVI can be performed successfully in patients with aortic disease or previous endovascular aortoiliac intervention. Simultaneous and sequential (T)EVAR is feasible. PMID: 31416046 [PubMed - as supplied by publisher]
Source: The Journal of Invasive Cardiology - Category: Cardiology Tags: J Invasive Cardiol Source Type: research
Abstract As the number of, and the indications for, structural heart interventions are increasing worldwide, the optimal secondary prevention to reduce device thrombosis is becoming more important. To date, most of the recommendations are empiric. The current review discusses mechanisms behind device-related thrombosis, the available evidence with regard to antithrombotic regimen after cardiac device implantation, as well as providing an algorithm for identification of risk factors for device thrombogenicity and for management of device thrombosis after implantation of patent foramen ovale and left atrial appendag...
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: Thromb Haemost Source Type: research
Authors: Wang TKM, Liao YB, Choi D, Harmos S, Haydcok D, Gerber I Abstract AIMS: A significant minority of patients undergoing mitral valve surgery (MVR) have indication for coronary artery bypass grafting (CABG). The risks of combination surgeries are not well appreciated and maybe more than additive. We compared the characteristics and outcomes of MVR+/-CABG performed at our centre. METHODS: Consecutive patients undergoing isolated MVR or with concurrent (MVR+)CABG at Auckland City Hospital during 2005-2012 were compared for baseline and operative characteristics and outcomes in univariable and multivariable ...
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
Authors: Gupta T, Kolte D, Khera S, Goel K, Villablanca PA, Kalra A, Abbott JD, Elmariah S, Fonarow GC, Rihal CS, Garcia MJ, Weisz G, Bhatt DL Abstract With the growing utilization of TAVR over the last decade, it is important to examine the impact of adoption of TAVR on the number of SAVRs and total number of AVRs. We observed a linear increase in the total number of AVRs performed in the United States that was mainly driven by a marked diffusion of TAVR, whereas the number of SAVRs remained relatively stable. The number of TAVRs increased in all age categories. In contrast, the number of SAVRs increased modestly ...
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
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