Early weight-loss surgery may improve type 2 diabetes, blood pressure outcomes
NIH-funded study followed teens, adults with long-term obesity five years after gastric bypass.
Conclusionclinicians should be aware of such condition in patients with history of bariatric surgery who present with long-standing, intermittent abdominal pain.
Publication date: Available online 4 June 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s): Alexander Dimitri Miras, Belén Pérez-Pevida, Madhawi Aldhwayan, Anna Kamocka, Emma Rose McGlone, Werd Al-Najim, Harvinder Chahal, Rachel L Batterham, Barbara McGowan, Omar Khan, Veronica Greener, Ahmed R Ahmed, Aviva Petrie, Samantha Scholtz, Stephen R Bloom, Tricia M TanSummaryBackgroundMany patients with type 2 diabetes do not achieve sustained diabetes remission after metabolic (bariatric) surgery for the treatment of obesity. Liraglutide, a glucagon-like peptide-1 analogue, improves glycaemic control and...
This study sheds new light on the complex changes in bone metabolism and ultimately bone density after metabolic surgery.
The foregut theory posits that proximal small intestine plays an important role in the improvement of type 2 diabetes (T2D) after Roux-en-Y gastric bypass (RYGB).
Gastric bypass surgery leads to dramatic weight loss and improvement in insulin resistance to the point of the resolution of type 2 diabetes in a majority of cases. These improvements in insulin sensitivity appear to be weight loss independent and occur immediately after bariatric surgery. The focus of the current review will be to summarize how the physiological changes that have been shown to arise from sustained weight loss after bariatric surgery affect other interrelated endocrine processes such as bone remodeling and improve obesity ‐related hypogonadal dysfunction. AbstractBariatric surgery is now the most widely ...
ConclusionsWe were able to develop an interactive estimation application to provide a population-based guidance for potential outcomes of LRYGB. This might be useful not only for health professionals but also for patients interested in learning potential outcomes in specific circumstances.
Early diagnosis of kidney disease in obese patients and in such with type 2 diabetes mellitus (T2D) can significantly improve treatment outcome. Serum uromodulin (sUMOD) may be a sensitive parameter for early detection of nephropathy.
ConclusionsRYGB ameliorates glucose and lipid metabolism accompanied by weight loss and calorie restriction. The liver exhibited a marked improvement in lipid accumulation after RYGB. The bile acids level, FXR, and its target transcriptional factor SHP expression were elevated. Meanwhile, our study demonstrated that the increased bile acids-FXR signaling, followed by the reduced hepatic gluconeogenesis, lipogenesis, and increased fatty acidβ oxidation may contribute to improved metabolic conditions after RYGB.
Conclusion: Decreased or normalized TSH levels after weight loss induced by RYGB might be mediated by the decline in leptin. There could be cross talk between adipose tissue and the HPT axis.Obes Facts 2019;12:272 –280
ConclusionsOAGB is a valid alternative for long-term weight loss and remission of comorbidities in childhood and adolescence. No cases of malnutrition or growth disorders were observed.