Anaphylaxis in pregnancy in the USA: Risk factors and temporal trends using national routinely collected data

ConclusionDespite increased rates of caesarean delivery in USA and consequent drug administration, there was no evidence of an increasing trend in anaphylaxis. Caesarean delivery and prior history of an allergic reaction allow the identification of women at risk of anaphylaxis. Not all women had clear risk factors and preparations should always be in place to ensure timely management if this uncommon event occurs.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research

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Conclusion Alternative antibiotic use for GBS prophylaxis is frequent with penicillin/cephalosporin allergies. Efforts to confirm allergy and perform penicillin hypersensitivity testing may increase compliance with guidelines for antibiotic administration. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: American Journal of Perinatology Reports - Category: Perinatology & Neonatology Authors: Tags: Original Article Source Type: research
ConclusionsDespite increased rates of cesarean delivery in the United States and consequent drug administration, there was no evidence of an increasing trend in anaphylaxis. Cesarean delivery and history of an allergic reaction allow the identification of women at risk of anaphylaxis. Not all women had clear risk factors, and preparations should always be in place to ensure timely management if this uncommon event occurs.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
This study — known as the Learning Early About Peanut or LEAP trial — showed that children at high risk of developing peanut allergies who are introduced to peanuts at 4 months to 6 months old had a significantly lower risk of developing a peanut allergy than those who waited until they were 5 years; 1.9% of the kids who had peanuts early developed an allergy, compared with 13.7% of the kids who waited. The LEAP trial formed the basis for Monday’s new recommendations, which encourage the early introduction of peanut products in infants at high risk for allergies. But most babies are not at high risk, and ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Food Allergies Source Type: news
Chances are, you or someone you know is one of the 10% of Americans with a documented penicillin allergy. But just because you were told you had a penicillin allergy, or had one in the past, does not mean you have one now. People with a penicillin allergy history have their allergy disproved with allergy testing more than 90% of the time. Penicillin: a primer Penicillin is part of a larger drug class called beta-lactam antibiotics, which include the common penicillins and cephalosporins. Common penicillins include ampicillin, amoxicillin, and Augmentin. Among other uses, penicillins are often used to treat ear infections, ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Allergies Health Tests and procedures Source Type: blogs
ConclusionsDuring severe anaphylaxis in mastocytosis patients DAO is likely released from heparin ‐sensitive gastrointestinal storage sites. The measured concentrations can degrade histamine, but DAO activity is compromised compared to pregnancy samples. For accurate histamine measurements during anaphylaxis DAO inhibition is essential to inhibit further histamine degradation after blood withd rawal. Determination of DAO antigen levels might be of clinical value to improve the diagnosis of mast cell activation.This article is protected by copyright. All rights reserved.
Source: Allergy - Category: Allergy & Immunology Authors: Tags: Original Article: Anaphylaxis Source Type: research
DiscussionThis trial will assess whether a single dose of doxycycline (400  mg) and metronidazole (400 mg) taken orally 2 hours before miscarriage surgery can reduce the incidence of pelvic infection in women up to 2 weeks after miscarriage surgery.Trial registrationRegistered with the ISRCTN (international standard randomised controlled trial number) registry: ISRCTN97143849. (Registered on April 17, 2013).
Source: Trials - Category: Research Source Type: clinical trials
AbstractPurpose of ReviewProgestogen hypersensitivity (PH) is a rare disorder which usually occurs in women of childbearing age with symptoms ranging from urticaria with or without angioedema, multiple organ involvement consistent with allergic anaphylaxis, to a spectrum of other non-evanescent skin eruptions. In this review, we present a clinical vignette of PH and discuss the clinical presentation and proposed pathomechanisms, diagnosis, and treatment of PH.Recent FindingsThe hypersensitivity symptoms are associated with exogenous progestin exposure (e.g., contraceptive medicines, in vitro fertilization therapy) or endog...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
ConclusionsAnaphylaxis is a rare severe complication of pregnancy and frequently the result of a reaction to antibiotic administration. This study highlights the seriousness of the outcomes of this condition for the mother. The low incidence is reassuring given the large proportion of the pregnant population that receive prophylactic antibiotics during delivery. Tweetable abstractAnaphylaxis is a rare severe complication of pregnancy and frequently the result of a reaction to antibiotic administration.
Source: BJOG: An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: Original Article Source Type: research
ConclusionsAnaphylaxis is a rare severe complication of pregnancy and frequently the result of a reaction to antibiotic administration. This study highlights the seriousness of the outcomes of this condition for the mother. The low incidence is reassuring given the large proportion of the pregnant population that receive prophylactic antibiotics during delivery.This article is protected by copyright. All rights reserved.
Source: BJOG: An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: Main Research Article Source Type: research
This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - Category: Allergy & Immunology Authors: Tags: Invited Review Source Type: research
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