Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions.

CONCLUSION: The Warburg effect is initiated in liver precancerous lesions in rats. STAT3 activation promotes the Warburg effect by enhancing the phosphorylation of PKM2 in transformed WB-F344 cells. PMID: 31086462 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31086462?dopt=Abstract

Source: World Journal of Gastroenterology : WJG - April 27, 2019 Category: Gastroenterology Authors: Bi YH, Han WQ, Li RF, Wang YJ, Du ZS, Wang XJ, Jiang Y Tags: World J Gastroenterol Source Type: research