Effect of artemisinin-piperaquine treatment on the electrocardiogram of malaria patients

CONCLUSIONS: AP may cause QT interval prolongation in some malaria patients but may not lead to TdP.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research

Related Links:

Conclusion: Mefloquine can be added safely to dihydroartemisinin-piperaquine in malaria treatment. PMID: 31182525 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
This study was performed in accordance with the ethical standards of the Institutional Animal Care and Use Committee (IACUC, approval FUA-007-14) from the Unidad de Biología Comparativa (UBA) at Pontificia Universidad Javeriana (PUJ, Bogotá, Colombia). All animal studies were conducted in accordance with the “Guide for the Care and Use of Laboratory Animals” from UBA-PUJ. The present study was described according to the Animal Research: Reporting in vivo Experiments (ARRIVE) criteria from the National Center for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) (32). Mice ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSIONS: Pyronaridine-artesunate was efficacious against uncomplicated P falciparum malaria, achieved a PCR-adjusted treatment failure rate of less than 5% at days 28 and 42, and may be at least as good as, or better than other marketed ACTs.Pyronaridine-artesunate increases the risk of episodes of raised ALT> 5 x ULN. This meets criteria for mild drug-induced liver injury. On one instance this was linked to raised bilirubin, indicating moderate drug-induced liver injury. No episodes of severe drug-induced liver injury were reported. The findings of this review cannot fully inform a risk-benefit assessment for an un...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
CONCLUSIONS: Three consecutive monthly courses of DHA/PQP were as safe as a single course. The absence of cumulative cardiotoxicity with repeated dosing support the use of monthly DHA/PQP as part of malaria elimination strategies. PMID: 30249696 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Summer may be winding down, but travel isn’t! Getting ready for a big trip abroad can be a lot of work — especially for people with health concerns. This travel tips checklist can pave the way for a smooth journey. Before your trip   Check for travel advisories You should be aware of health or political circumstances relevant to your destination(s). The US Department of State has a number of resources for the traveler, including postings on health and security alerts for specific countries.   Check the CDC’s traveler health information There is a wealth of information here, includ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Source Type: blogs
Conditions:   Severe Sepsis;   Malaria Interventions:   Procedure: Lung Ultrasound examination;   Procedure: Compression ultrasonography (CUS);   Procedure: Echocardiography;   Procedure: Inferior Vena Cava ultrasound;   Procedure: Passive leg raising test (PLR);   Procedure: Orthogonal polarization spectral imaging (OPS);   Pro cedure: Urine collection (Foley catheter);   Procedure: Venous blood samplings;   Procedure: Electrocardiogram Sponsors...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 28 June 2018Source: Journal of Cardiology CasesAuthor(s): Abdullah Cader, Sheldon M. Singh, Mohammad I. ZiaAbstractBrugada syndrome is typically an autosomal dominant genetic disorder with variable expression, characterized by three specific electrocardiogram (ECG) patterns. While Type I Brugada ECG pattern is used as a classic marker for the disease, it is generally masked from ECG except in special cases such as malaria-induced fever. This vignette highlights a unique clinical scenario that can lead to the unmasking of Brugada type 1 pattern.
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
ConclusionsPharmacokinetic–pharmacodynamic modelling and simulation in healthy adult volunteers suggested that therapeutic doses of DHA–piperaquine in the prevention or treatment of P. falciparum malaria are unlikely to be associated with dangerous QT prolongation.
Source: British Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: PHARMACOKINETIC DYNAMIC RELATIONSHIPS Source Type: research
More News: Cardiology | Electrocardiogram | Heart | Malaria | Study | Tropical Medicine