Myocarditis in Cynomolgus Monkeys Following Treatment with Immune Checkpoint Inhibitors.

CONCLUSIONS: We have developed a monkey model characterized by multiple organ toxicities including myocarditis. This model may provide insight into the immune mechanisms and facilitate biomarker identification for ICI-associated irAEs.
PMID: 31085720 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - May 12, 2019 Category: Cancer & Oncology Authors: Ji C, Roy MD, Golas J, Vitsky A, Ram S, Kumpf SW, Martin M, Barletta F, Meier W, Hooper AT, Sapra P, Khan NK, Finkelstein M, Guffroy M, Buetow BS Tags: Clin Cancer Res Source Type: research