Intra-tracheal amikacin spray delivery in healthy mechanically ventilated piglets

ConclusionNebulization remains the most reliable and simple technique to deliver inhaled amikacin uniformly to the lung during mechanical ventilation. Further development of tracheal sprays is required to take advantage of potential benefits related to high drug output and low extra-pulmonary deposition in large animals.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research

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A better understanding of the bacterial pathogens associated with diabetic foot ulcers will help guide the choice of antibiotic therapies.Wounds
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Journal Article Source Type: news
Conclusions: The majority of S. aureus IAIs were methicillin-susceptible S. aureus. All children with immediate implant removal and most children with retained implants were treated successfully with surgery and antibiotic therapy.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
ConclusionBoth protocols yielded high overall success rates. Immediate empirical antibiotics can be used safely without additional bacterial resistance and may contribute to increased success rates.
Source: European Journal of Trauma and Emergency Surgery - Category: Emergency Medicine Source Type: research
CONCLUSION: Our findings showed that the majority of patients hospitalized in different wards of hospitals have experienced the urinary tract infection caused by P. aeruginosa. According to the genotyping results, a high diversity of the P. aeruginosa population was observed in the patients with UTI. Our results can provide a better understanding of the P. aeruginosa genotype distribution and epidemiology of infection, which can be applied as basic data for future antibiotic therapies. PMID: 31300119 [PubMed - in process]
Source: Comparative immunology, microbiology and infectious diseases. - Category: Allergy & Immunology Authors: Tags: Comp Immunol Microbiol Infect Dis Source Type: research
A periprosthetic joint infection (PJI) is a serious complication after joint arthroplasty and is accompanied by increased morbidity and mortality.1,2 Clinical outcome is highly dependent on host related factors, clinical characteristics, the causative microorganism, and the applied antimicrobial therapy and surgical techniques.4, 10, 11 Therefore, optimising treatment and composing tailored strategies are crucial to improve clinical outcome. We recently demonstrated that late acute PJIs have a relatively high failure rate when treated with surgical debridement and implant retention (DAIR).
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
Authors: Večeřa Z, Krejčí T, Krajča J, Kanta M, Lipina R Abstract BACKGROUND: This work aims to determine how antibiotic therapy influences MR spectroscopic findings in patients undergoing treatment for pyogenic brain abscess. METHODS: This prospective, single center study included all patients who received treatment for brain abscesses at the Neurosurgery Department of University Hospital Ostrava between 2012-2017. Pre-operative MR imaging was carried out on all patients including diffusion-weighted imaging and in vivo single-voxel proton spectroscopy with intermediate echo time. The following facto...
Source: Journal of Neurosurgical Sciences - Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research
Authors: Iwata K, Toma T, Yachie A Abstract A 38-year-old Japanese man without any significant past medical history was referred to our clinic to undergo further examination for a "refractory infection in his joints". He suffered recurrent migratory polyarthritis starting from bilateral knees to his right elbow. Certain antibiotic therapies appeared to improve his symptoms, but the symptoms recurred due to the migratory nature of arthritis. A diagnosis of familial Mediterranean fever (FMF) was considered and diagnostic tests were performed. Not many differential diagnoses exist for migratory polyarthritis...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
CONCLUSION: The knowledge of the characteristics that are associated with prolonged stay among patients with cellulitis/erysipelas may be relevant to improve health care, by reducing the length of hospital stay and associated risks and costs. PMID: 31292026 [PubMed - in process]
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
Retrospective analysis of data from 43 US hospitals suggest 67.8% of patients received excess antibiotic therapy which was not associated with lower rates of any adverse outcomes, including death, readmission, emergency department visit, or Clostridium difficile infection.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
ConclusionsThis incidence of SD sustained by Granulicatella adiances could be underestimated due to their particular microbiological conditions requested for their cultures. However, this infection should be suspected in cases of culture-negative SD, especially when associated with endocarditis.
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
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