Assessing driving risk in patients with glaucoma

ABSTRACT Glaucoma is the leading cause of irreversible blindness worldwide and can affect a broad array of daily activities, including driving. Recently, studies investigating the relationship between driving performance and glaucoma have received a great deal of interest. Assessment of driving behavior is not straightforward because driving is a complex skill involving significant multi-tasking ability. In this review, we summarize recent work from clinical studies investigating how glaucoma can affect driving performance. Patients with glaucoma are more likely to be involved in motor vehicle collisions when compared to healthy subjects. Here we describe how conventional functional tests performed in glaucoma patients, such as visual field measurements via standard automatic perimetry, are associated with driving performance. However, the risk of motor vehicle collisions is not entirely attributable to visual field impairment in glaucoma, suggesting that other factors also account for both driving safety and performance. Finally, we show different studies suggesting that parameters from driving simulators can be helpful because they can identify the impact of visual loss on complex situations.RESUMO O glaucoma é a principal causa de cegueira irreversível em todo o mundo e pode afetar uma ampla gama de atividades diárias, incluindo a direção veicular. Recentemente, estudos que investigam a relação entre o desempenho na condu&cc...
Source: Arquivos Brasileiros de Oftalmologia - Category: Opthalmology Source Type: research

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Elevated intraocular pressure (IOP) due to insufficient aqueous humor outflow through the trabecular meshwork and Schlemm's canal (SC) is the most important risk factor for glaucoma, a leading cause of blindness worldwide. We previously reported loss of function mutations in the receptor tyrosine kinase TEK or its ligand ANGPT1 cause primary congenital glaucoma in humans and mice due to failure of SC development. Here, we describe a novel approach to enhance canal formation in these animals by deleting a single allele of the gene encoding the phosphatase PTPRB during development. Compared toTek haploinsufficient mice, whic...
Source: eLife - Category: Biomedical Science Tags: Developmental Biology Human Biology and Medicine Source Type: research
-rui Li Glaucoma is a serious eye disease that can cause permanent blindness and is difficult to diagnose early. Optic disc (OD) and optic cup (OC) play a pivotal role in the screening of glaucoma. Therefore, accurate segmentation of OD and OC from fundus images is a key task in the automatic screening of glaucoma. In this paper, we designed a U-shaped convolutional neural network with multi-scale input and multi-kernel modules (MSMKU) for OD and OC segmentation. Such a design gives MSMKU a rich receptive field and is able to effectively represent multi-scale features. In addition, we designed a mixed maximum loss mini...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Conclusions: Collectively, this work not only extended our understanding of the molecular characteristics of PCG, but also presented glycine as a potential biomarker for earlier diagnosis and may provide new therapeutic strategies for the disease. PMID: 31588173 [PubMed - in process]
Source: Molecular Vision - Category: Molecular Biology Tags: Mol Vis Source Type: research
A child receives treatment in the northeastern district of Mymensingh, Bangladesh. Credit: Naimul Haq/IPS By External SourceGENEVA, Oct 8 2019 (IPS) A staggering 2.2 billion people already suffer from eye conditions and visual impairment today, but the global need for eye care is set to increase “dramatically”, with lack of exercise a key factor, the UN health agency said on Tuesday, unveiling its first ever report on vision across the world. While welcoming recent successes in eliminating common conditions such as trachoma in eight countries, the World Health Organization (WHO) highlighted evidence indicating ...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Global Headlines Health TerraViva United Nations Source Type: news
Conclusions: The 2-year results indicate that there is a place for the Boston type 1 KPro in the management of corneal blindness. However, there is scarce evidence regarding its medium- and long-term efficacy and safety. The high rate of reported complications necessitates strict patient selection and stringent follow-up.
Source: Cornea - Category: Opthalmology Tags: Review Source Type: research
The retinal nerve fiber layer (RNFL) is one of the most affected parts of the eye retina by glaucoma disease. Progression of this disease results in RNFL texture changes and can be observed from the fundus images and RNFL thickness; thus, the glaucoma is one of the ocular diseases contributing to most of the blindness worldwide. There are increasing demands for medical image–based computer-aided diagnosis system based on fundus image for glaucoma detection. Thus, the RNFL thickness changes can be assessed by optical coherence tomography. However, an examination using the optical coherence tomography device is rather ...
Source: Journal of Clinical Engineering - Category: Medical Devices Tags: FEATURE ARTICLES Source Type: research
Primary angle-closure disease (PACD) is defined by the development of appositional contact or peripheral anterior synechiae (PAS) between the iris and trabecular meshwork, leading to impaired aqueous outflow and elevation of intraocular pressure (IOP), which increases the risk for developing glaucomatous optic nerve damage. The development of optic nerve damage in the context of iridocorneal angle closure defines primary angle-closure glaucoma (PACG). While PACG is less prevalent than primary open-angle glaucoma (POAG), PACG is a more frequent cause of bilateral blindness. Historically, clinical management of PACG resemble...
Source: JAMA Ophthalmology - Category: Opthalmology Source Type: research
CONCLUSION: The leading causes of visual impairment and blindness in this study are avoidable and treatable. Health education, appropriate intervention, and support groups should be encouraged. This may serve to reduce the burden of visual impairment and improve the QOL of patients.
Source: Middle East African Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
R KrishnadasIndian Journal of Ophthalmology 2019 67(10):1655-1656
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial. People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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