Preclinical and clinical evaluation of a novel synthetic bioresorbable, on demand light activated sealant in vascular reconstruction.

CONCLUSIONS: The new synthetic on-demand light activated PGSA-based SETALIUMTM VASCULAR SEALANT investigated in our studies demonstrated good biocompatibility, sustained and gradual surface based bioresorption, and acceptable safety profile in animal studies. In addition, the first in-human use showed that the sealant is a safe and effective alternative to achieve fast and controlled hemostasis in vascular carotid reconstructions. A larger randomized controlled study will allow further validation of these encouraging preliminary results.
PMID: 31089086 [PubMed - as supplied by publisher]

Source: The Journal of Cardiovascular Surgery - May 9, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Pellenc Q, Touma J, Coscas R, Edorh G, Pereira M, Karp J, Castier Y, Desgranges P, Alsac JM Tags: J Cardiovasc Surg (Torino) Source Type: research