Strategizing biodegradable polymeric nanoparticles to cross the biological barriers for cancer targeting

Publication date: Available online 15 May 2019Source: International Journal of PharmaceuticsAuthor(s): Hira Choudhury, Bapi Gorain, Manisha Pandey, Rajneet Kaur, Prashant KesharwaniAbstractThe biological barriers in the body have been fabricated by nature to protect the body from foreign molecules. The successful delivery of drugs is limited and being challenged by these biological barriers including gastrointestinal tract, brain, skin, lungs, nose, mouth mucosa and immune system. In this review article, we envisage to understand the functionalities of these barriers and revealing various drug-loaded biodegradable polymeric nanoparticles to overcome these barriers and deliver the entrapped drugs to the cancer targeted site. Apart from it, tissue specific multifunctional ligands, linkers and transporters when employed imparts an effective active delivery strategy by receptor mediated transcutosis. Together, these strategies enable to deliver various drugs across the biological membranes for the treatment of solid tumors and malignant cancer.Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research