Persistence of intrathecal oligoclonal B cells and IgG in multiple sclerosis
In multiple sclerosis (MS), B cells are trafficking across the blood-brain barrier, but it is not known how this relates to the synthesis of oligoclonal IgG. We used quantitative mass spectrometry of oligoclonal bands and high-throughput sequencing of immunoglobulin heavy-chain variable transcripts to study the longitudinal B cell response in the cerebrospinal fluid (CSF) and blood of two MS patients. Twenty of 22 (91%) and 25 of 28 (89%) of oligoclonal band peptides persisted in samples collected 18 months apart, in spite of a dynamic exchange across the blood-CSF barrier of B lineage cells connecting to oligoclonal IgG.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Alina Tomescu-Baciu, Jorunn N. Johansen, Trygve Holm øy, Victor Greiff, Maria Stensland, Gustavo Antonio de Souza, Frode Vartdal, Andreas Lossius Source Type: research