PD-L1 Expression and Its Regulation in Lung Adenocarcinoma with ALK Translocation

ConclusionsWe demonstrate that ALK translocation can upregulate PD-L1 expression by activating ERK, STAT3 and AKT pathways. ALK inhibitor combined with a PD-L1-targeted therapy may be a potential strategy in ALK-translocated lung adenocarcinoma patients.

http://link.springer.com/10.1007/s12539-019-00331-0

Source: Interdisciplinary Sciences, Computational Life Sciences - May 15, 2019 Category: Bioinformatics Source Type: research

More News: Adenocarcinoma | Bioinformatics | Genetics | Translocation