PD-L1 Expression and Its Regulation in Lung Adenocarcinoma with ALK Translocation

ConclusionsWe demonstrate that  ALK translocation can upregulate PD-L1 expression by activating ERK, STAT3 and AKT pathways. ALK inhibitor combined with a PD-L1-targeted therapy may be a potential strategy in ALK-translocated lung adenocarcinoma patients.
Source: Interdisciplinary Sciences, Computational Life Sciences - Category: Bioinformatics Source Type: research

Related Links:

Whole genome and transcriptome sequencing technologies have led to the identification of many long non-coding RNAs (lncRNAs) and stimulated the research of their role in health and disease. LncRNAs participate in the regulation of critical signaling pathways including cell growth, motility, apoptosis, and differentiation; and their expression has been found dysregulated in human tumors. Thus, lncRNAs have emerged as new players in the initiation, maintenance and progression of tumorigenesis. PVT1 (plasmacytoma variant translocation 1) lncRNA is located on chromosomal 8q24.21, a large locus frequently amplified in human can...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsTaken together, this study suggests that STAT3/FoxO3a/p27Kip1 signaling pathway is involved in the anticancer effects of HCQ, and provides preliminary evidence for therapeutic prospects of HCQ alone in LUAD.Graphical abstract
Source: Life Sciences - Category: Biology Source Type: research
In this study, we analyzed the bacterial energetic requirements associated with these cellular alterations. Mutant strains lacking Cagα, Cagβ, or CagE (putative ATPases corresponding to VirB11, VirD4, and VirB4 in prototypical T4SSs) were capable of T4SS core complex assembly but defective in CagA translocation into host cells. Thus, the three Cag ATPases are not functionally redundant. Cagα and CagE were required for H. pylori-induced NF-B activation, IL-8 secretion, and TLR9 activation, but Cagβ was dispensable for these responses. We identified putative ATP-binding motifs (Walker-A and Walker-B) in...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Molecular Pathogenesis Source Type: research
This study aimed to explore potential targets and mechanisms of IPF.Main methodsmRNA and microRNA arrays were used to analyze differentially expressed genes and miRNAs. Several essential targets of TGF-β-SMADs and TGF-β-PI3K-AKT pathways were detected.Key findingsmiR-31 and miR-184 expression levels were positively correlated with smad6 and smad2/akt expression levels in IPF patients. TGF-β could induce miR-31 and suppress miR-184 levels in A549 cells. miR-31 was confirmed to bind to the smad6-3′UTR and functionally suppress its expression. Down-regulated SMAD6 enhanced SMAD2/SMAD4 dimer formation and ...
Source: Life Sciences - Category: Biology Source Type: research
CYLD expression in dendritic cells involved in the immunoregulation of pulmonary adenocarcinoma via NF-κB pathway. Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):137-142 Authors: Yu Q, Lei Y, Huang Y, Zhang J, Chen Y, Chen K, Lin J, Sun S, Lin X Abstract Our previous study found that IL33 repressed the growth of pulmonary adenocarcinoma (PA) via regulation of dendritic cells (DCs). However, the molecular mechanism of DCs in PA is still unclear. The present work showed that CYLD-/- mice have a shorter survival rate of PA, and knockout CYLD in DCs also repress the progression of PA in mice. Subsequ...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Secretory carcinoma, described as mammary analog secretory carcinoma, is a recently described tumor of salivary glands that is defined by its histologic, immunophenotypic, and genetic similarities to the secretory breast carcinoma and is characterized by ETV6 translocation. The first description of mammary analog secretory carcinoma was reported by Skalova et al. in 2010. Retrospective studies showed that some tumors of salivary glands such as acinic cell carcinoma, low-grade salivary duct carcinoma, adenocarcinoma/cystadenocarcinoma not otherwise specified (NOS), and low-grade mucoepidermoid carcinoma were misdiagnosed.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
Publication date: Available online 20 November 2019Source: Materials Today CommunicationsAuthor(s): Katerina N. Panagiotaki, Konstantinos Spyrou, Michael Zachariadis, Harris Pratsinis, Antonios Kouloumpis, Lamprini G. Boutsika, Apostolos Enotiadis, Dimitrios Gournis, Emmanuel P. Giannelis, Zili SideratouAbstractA novel nanoscale drug delivery system based on monodispersed non-porous ionic silica nanospheres (NISNs) decorated with phosphonated active sides homogeneously distributed all over their surface, was developed. Doxorubicin (DOX), a well-known antitumor drug, was successfully loaded on the surface of the silica nano...
Source: Materials Today Communications - Category: Materials Science Source Type: research
In conclusion, Acacetin induces mitochondrial ROS-mediated cell death in a caspase-independent manner in SW480 and HCT-116 colon carcinoma cells by inducing apoptosis inducing factor (AIF), which may potentiate its anticancer and chemotherapeutic prospects against colorectal carcinoma. PMID: 31734898 [PubMed - as supplied by publisher]
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
ConclusionsGastrointestinal MANEC is a microsatellite stable tumor with nodular growth, which components might originate from a CD44-positive stem-like precursor cell. Lymph node status remains the most reliable prognostic parameter and agressivity seems to not be influenced by tumor budding degree or EMT-related features. The histologic aspect of metastatic component (neuroendocrine versus adenocarcinoma) should be included in the histopathological reports and might be used for establishing the proper-targeted therapy of MANEC.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
CONCLUSIONS: Gastrointestinal MANEC is a microsatellite stable tumor with nodular growth, which components might originate from a CD44-positive stem-like precursor cell. Lymph node status remains the most reliable prognostic parameter and agressivity seems to not be influenced by tumor budding degree or EMT-related features. The histologic aspect of metastatic component (neuroendocrine versus adenocarcinoma) should be included in the histopathological reports and might be used for establishing the proper-targeted therapy of MANEC. PMID: 31704155 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - Category: Pathology Authors: Tags: Pathol Res Pract Source Type: research
More News: Adenocarcinoma | Bioinformatics | Genetics | Translocation