Association between benzodiazepine use in early pregnancy, miscarriage risk

(JAMA Network) Benzodiazepines are a class of drugs used to treat anxiety, insomnia and mood disorders. This observational study examined the risk of miscarriage associated with their use in early pregnancy by drug class, specific agent and short- or long-acting formulation in about 442,000 pregnancies in Canada from 1998 through 2015.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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Authors: Mochizuki N, Ano S, Kikuchi N, Sakai C, Masuda M, Kondo Y, Ishii Y Abstract A 54-year-old man started to take oren-gedoku-to (coptis detoxifying decoction) because he was experiencing chronic hot flashes, night sweats and insomnia. He developed a high fever from the day of intake. At day 17, he stopped taking oren-gedoku-to because of malaise and chills, and he was admitted to our hospital. Drug-induced pneumonitis was suspected, and all drugs were stopped. Consequently, his symptoms, laboratory data and chest X-ray findings markedly improved. The results of a lymphocyte stimulation test were positive for ...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
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Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
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Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
This report therefore uses quality assurance data looking into whether sensory processing sensitivity (SPS) affects treatment outcome among patients with OCD. SPS is a personality trait regarding heightened levels of emotional reactivity and deeper cognitive processing of emotional stimuli. Patients received concentrated exposure treatment for obsessive-compulsive disorder (OCD). They were assessed with one of the most widely used questionnaires for measuring SPS, the Highly Sensitive Person Scale (HSPS). Analyses tested whether HSPS scores at pre-treatment affected treatment outcome, and if sensitivity changed from pre-to...
Source: Journal of Obsessive Compulsive and Related Disorders - Category: Psychiatry Source Type: research
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Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
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In Reply Although we agree with Wisner and Yonkers that our findings can potentially be explained by residual confounding by indication, we have performed several additional sensitivity analyses to validate our results. First, the impact of the diseases for which benzodiazepines are prescribed was addressed in the main analysis where statistical adjustments were made for the diagnoses of the 2 main indications (mood and anxiety disorders and insomnia) and documented proxies of these diseases (concomitant exposure to antidepressants and/or antipsychotics, psychiatrist visits, comorbidities, and emergency department visits a...
Source: JAMA Psychiatry - Category: Psychiatry Source Type: research
Pregnant women who take a class of drugs that's often prescribed for anxiety or insomnia may run a higher risk of miscarriage, a new study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
The use of any benzodiazepines during early pregnancy may increase the risk of miscarriage, according to astudy published today inJAMA Psychiatry.“The findings suggest that health care clinicians should carefully evaluate the risk-benefit ratio of benzodiazepines for the treatment of insomnia and mood or anxiety disorders in early pregnancy,” wrote Odile Sheehy, M.Sc., of the Centre Hospitalier Universitaire Sainte-Justine in Montreal and colleagues. “[I]f benzodiazepines are needed, they should be prescribed for short durations.”Sheehy and colleagues analyzed data from the Quebec Pregnancy Cohort, ...
Source: Psychiatr News - Category: Psychiatry Tags: benzodiazepines JAMA Psychiatry Odile Sheehy pregnancy Quebec Pregnancy Cohort Source Type: research
You couldn’t get pregnant easily, and needed fertility treatments. You had a miscarriage. Or several. You developed complications during your pregnancy. You delivered your baby preterm. Every single one of Parijat Deshpande’s clients feels like their bodies have betrayed them because of the above reasons. Deshpande, MS, is a perinatal mind-body wellness counselor and high-risk pregnancy expert, who helps women navigate stress so they can manage pregnancy complications and give their baby a strong start to life. Psychologist Julie Bindeman, PsyD, works with women struggling with reproductive challenges, depressi...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Addiction General Grief and Loss Health-related Mental Health and Wellness Self-Help Stress Women's Issues Betrayal Fertility miscarriage Parenthood Pregnancy Source Type: blogs
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