New drug could help treat neonatal seizures

(Penn State) A new drug that inhibits neonatal seizures in rodent models could open up new avenues for the treatment of epilepsy in human newborns.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Authors: Wang XF, Ge TT, Fan J, Yang W, Li B, Cui RJ Abstract [This corrects the article DOI: 10.18632/oncotarget.20606.]. PMID: 31191827 [PubMed - in process]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Makke Y, Abou-Khalil B Abstract Introduction Brivaracetam (BRV) is an analog of levetiracetam (LEV) with 15-30 times greater affinity to SV2A and greater brain permeability than LEV. These properties have stimulated interest in its clinical trial data and post marketing experience. Areas covered The authors provide a background on epilepsy and its treatment, discuss the racetam family of antiepileptic drugs to which BRV belongs, and then discuss BRV properties and its efficacy and tolerability in the treatment of epilepsy. Expert opinion While preclinical data suggest broad spectrum of efficacy, BRV is only a...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Conclusions: Poor outcomes in new-onset status epilepticus were associated with older age as well as predominantly progressive or remote symptomatic disease. Further prospective investigations assessing the course and outcomes of these patients would be useful in management and prognostication.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Neurologic Critical Care Source Type: research
FRIDAY, June 14, 2019 -- There is an increased risk for behavioral problems in children of mothers with epilepsy who take common antiepileptic drugs during pregnancy, according to a study published online June 5 in Epilepsia. Yfke Huber-Mollema,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Researchers at Ben-Gurion University of the Negev (BGU) and Cedars-Sinai Medical Center in Los Angeles said that for the first time they have duplicated a patient's blood-brain barrier (BBB) with stem cells. In turn, the research team said this can be used to develop personalized medicine and new techniques to research brain disorders. The new research, published in the journal Cell Stem Cell, is a collaboration between Dr. Gad Vatine of BGU's Regenerative Medicine and Stem Cell Research Center and Department of Physiology and Cell Biology and Dr. Clive N. Svendsen, of Cedars-Sinai Medical Center in Los Angeles. The BBB bl...
Source: MDDI - Category: Medical Devices Authors: Tags: Imaging Source Type: news
The medicine, pregabalin (Lyrica), comes from a class of drugs called gabapentinoids.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Objective: The adenosinergic system may influence excitability in the brain. Endogenous and exogenous adenosine has anticonvulsant activity, presumably by activating A1 receptors. Adenosine A1 receptor agonist 2-chloro-N6-cyclopentyladenosine (CCPA) may thus bolster anticonvulsant effect, but its action and amount of A1 receptors in different developmental stages is not known. Methods: Hippocampal epileptic afterdischarges (ADs) were elicited in 12-, 15-, 18-, 25-, 45-, and 60-day-old rats. Stimulation and recording electrodes were implanted into the dorsal hippocampus. The A1 receptor agonist 2-chloro-N6-cyclopentyladen...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: MRgFUS offers a noninvasive option for seizure tract disruption. DTI identifies fornix-fimbria and optic radiations to localize optimal ablation targets and critical surrounding structures, minimizing risk of postoperative visual field deficits. This theoretical modeling study provides the necessary groundwork for future clinical trials to apply this novel neurosurgical technique to patients with refractory MTLE and surgical contraindications, multiple prior surgeries, or other factors favoring noninvasive treatment. PMID: 31200385 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
CONCLUSIONS: The widespread contralateral hippocampal FC changes after surgery may be a reflection of an ongoing epileptogenic progression that has been altered by the surgery, rather than a direct result of the surgery itself. This network evolution may contribute to long-term seizure outcome. Therefore, the combination of presurgical network mapping with the understanding of the dynamic effects of surgery on the networks may ultimately be used to create predictors of the likelihood of long-term seizure recurrence in individual patients after mTLE surgery. PMID: 31200384 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
ConclusionKCNQ2 ‐related epilepsy led to varied outcomes (from benign to severe) in our patients.KCNQ2 mutations accounted for 13% of patients with seizure onset before 2  months old in our study.KCNQ2 mutations can cause different phenotypes in children. p.(Pro 285Thr) is a novel mutation, and the p.(Pro 285Thr), p.(Ser247Leu), and p.(Thr287Ile) variants can cause neonatal ‐onset epileptic encephalopathy.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
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