Endocrine and reproductive profile of boys and young adults conceived after ICSI

Purpose of review The impact of intracytoplasmic sperm injection (ICSI), on the reproductive health of the offspring is largely unknown. Here we provide a comprehensive overview of the endocrine and reproductive profile in boys and young male adults born after ICSI using ejaculated spermatozoa alleviating male factor infertility in their parents. Recent findings Levels of testosterone, anti-Müllerian hormone and inhibin B were found comparable in prepubertal and pubertal boys conceived by ICSI when compared with levels in boys conceived spontaneously. Also, at young adulthood, mean levels of reproductive hormones did not differ from control peers. However, semen analysis showed significantly lower sperm concentration, total sperm count and total motile sperm count when compared with controls. Furthermore, the risk of having sperm concentration and sperm count below the reference values was increased in ICSI offspring while sperm parameters did not correlate in paired father-son semen analysis. Summary Although endocrine gonadal function was normal at puberty, exocrine function at young adulthood was not. We observed decreased semen quality and quantity in young adults conceived by ICSI performed to circumvent male factor infertility. The possibility of transgenerational transmission of impaired spermatogenesis after ICSI needs further investigation.
Source: Current Opinion in Obstetrics and Gynecology - Category: OBGYN Tags: FERTILITY, IVF AND REPRODUCTIVE GENETICS: Edited by Emre Seli and Juan A. GarcĂ­a Velasco Source Type: research

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AbstractPurposeThe purpose of the study was to assess the fertilization rate and embryo development in sibling human oocytes after split insemination in patients with and without isolated teratozoospermia.MethodsA prospective cohort study at a university affiliated reproduction center was performed. Hundred and three patients during the time periods 01-2013 to 12-2015 had split insemination ordered for their first IVF cycle. The primary outcome measured was fertilization rate. Secondary outcomes were the number and quality of embryos.ResultsMature oocytes at the time of collection were assigned as follows: 558 to IVF and 5...
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
Condition:   Infertility Interventions:   Procedure: IVF;   Procedure: ICSI Sponsor:   Copenhagen University Hospital, Hvidovre Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The original article unfortunately contained 2 mistakes.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
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Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
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Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
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Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
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Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
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Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
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Source: Asian Journal of Andrology - Category: Urology & Nephrology Authors: Tags: Asian J Androl Source Type: research
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Source: Asian Journal of Andrology - Category: Urology & Nephrology Authors: Tags: Asian J Androl Source Type: research
More News: Boys | Genetics | Hormones | ICSI (Intracytoplasmic Sperm Injection) | Infertility | OBGYN | Reproduction Medicine