A Low-Fat Diet May Lower the Risk of Dying from Breast Cancer
In this study, volunteers were provided with dietary guidelines to follow about what to eat. “Until this study, we lacked any data from a prospective randomized control trial, which is the gold standard, for showing that a dietary approach really does reduce the risk of dying from breast cancer,” says Dr. Neil Iyengar, a medical oncologist at Memorial Sloan Kettering Cancer Center, who was not involved in the study. “Many of us who are proponents of considering diet and exercise in the cancer treatment plan are excited by this trial data because it is the first to show in a very robust way that we can improve outcomes and prevent cancer-related deaths just by changing the diet.” In a separate sub-study, the research team also showed that the longer women were on the modified diet, the lower their risk of death during the study period. The results should give doctors more confidence in considering diet when discussing treatment options with women who are diagnosed with breast cancer. While the study did not find a significant connection between dietary changes and the incidence of new breast cancer, the results do suggest that modifying the diet can lower a woman’s risk of dying from any cause, or from breast cancer, if she is diagnosed with the disease. The reason for that, says Iyengar, may have to do with the diet’s “dose.” It’s possible, for example, that the effect of the dietary change is greater on tiny tumors in the...
The U.S. Food and Drug Administration (FDA) said on Friday that it had approved Novartis AG's treatment in combination with a hormone therapy for postmenopausal women, as well as for men, with a form of advanced breast cancer.
CONCLUSIONS: This study demonstrates the importance of tumor microenvironment-derived factors for the development of AI resistance. These resistant models did not utilize the same resistance mechanism, suggesting that flexible strategies are essential in conquering resistance. PMID: 31119683 [PubMed - as supplied by publisher]
Transgender people on hormones, cisgender people should follow same breast cancer screening guidelines
CONCLUSIONS: This article provides reliable estimates on the burden of Italian women with breast cancer who, once tested with multigene testing, could potentially have their treatment changed to hormone therapy only. PMID: 31088341 [PubMed - as supplied by publisher]
A study published in theBMJhas suggested that transgender women are at a greater risk of developing breast cancer after hormone replacement therapy.Daily Mail
Researchers found that trans women on hormone therapy had a higher breast cancer risk than the general male population but lower than the general female population.
WEDNESDAY, May 15, 2019 -- Transgender women on gender-confirming hormone therapy have increased odds of breast cancer, but the overall risk is low and not as high as it is for the general female population, a new study finds. Trans women are those...
MHT containing natural estrogen and natural progesterone and some progestogens, is an effective treatment and is safer to the breast than high dose (0,625 mg or more) of equine estrogen with MPA. This latter treatment is associated with a higher incidence of breast cancer, in the range of the higher incidence of breast cancer due to drinking two or more alcohol drinks per day or gaining five of or more kilograms of weight. In women, at risk for breast cancer, with menopausal complaints special attention much be made to prescribe breast safe hormonal therapy.
Objective: Menopausal hormone therapy (MHT) can be performed using sequential or continuous combined regimens. Comparing in-vitro the proliferation of breast cancer cells using these different regimens could lead to suggestions if there may be a different risk of breast cancer which until now is not known. In addition, the aim also was to further investigate the importance of PGRMC1 for hormone induced proliferation using T47D breast cancer cells. This cell line recently has been recommended for breast cancer research.