Clostridium difficile infection objectives

These resources set out the objectives for acute trusts and clinical commissioning groups to make continuous improvement in Clostridium difficile infection (CDI) care.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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This study was undertaken to evaluate the antimicrobial resistance patterns of toxigenic C. difficile isolates cultured from diarrhoeal stool samples of hospitalised patients with suspected CDI in three tertiary care hospitals in Tehran, Iran.MethodsTwo hundred and fifty diarrhoeal stool samples were investigated by toxigenic culture using cycloserine-cefoxitin-fructose agar and the VERO cell line. Antimicrobial susceptibility to metronidazole, vancomycin, clindamycin, tetracycline, and moxifloxacin was performed by disk diffusion and Etest methods on Brucella Blood Agar supplemented with hemin and vitamin K.ResultsThirty-...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 12 June 2019Source: Journal of Hospital InfectionAuthor(s): Stefanie Gemein, Jürgen Gebel, Bärbel Christiansen, Heike Martiny, Lutz Vossebein, Florian H.H. Brill, Maja Decius, Maren Eggers, Torsten Koburger-Janssen, Maren Meckel, Sebastian Werner, Birgit Hunsinger, Thomas Selhorst, Günter Kampf, Martin ExnerSummarySporicidal surface disinfection is recommended to control transmission of Clostridium difficile in healthcare facilities. EN 17126 provides a method to determine the sporicidal activity in suspension and has been approved as a European standard. In addition, a spo...
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
The agency said two patients received donated stool that had not been screened for drug-resistant germs, leading it to halt clinical trials until researchers prove proper testing procedures are in place.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Drug Resistance (Microbial) Antibiotics fecal transplant Clostridium Difficile (Bacterium) E Coli (Bacteria) Food and Drug Administration Digestive Tract your-feed-healthcare Source Type: news
Newly revealed links between inflammation, obesity and cardiometabolic syndrome have created opportunities to try previously unexplored therapeutic modalities in these common and life-risking disorders. One potential modulator of these complex disorders is the gut microbiome, which was described in recent years to be altered in patients suffering from features of cardiometabolic syndrome and to transmit cardiometabolic phenotypes upon transfer into germ-free mice. As a result, there is great interest in developing new modalities targeting the altered commensal bacteria as a means of treatment for cardiometabolic syndrome. ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 12 June 2019Source: Journal of Hospital InfectionAuthor(s): Stefanie Gemein, Jürgen Gebel, Katrin Steinhauer, Bärbel Christiansen, Heike Martiny, Bernhard Meyer, Christiane Ostermeyer, Hans-Joachim Rödger, Lutz Vossebein, Lars Paßvogel, Florian H.H. Brill, Maja Decius, Maren Eggers, Torsten Koburger-Janssen, Maren Meckel, Heike Vogelsang, Sebastian Werner, Birgit Hunsinger, Thomas Selhorst, Günter KampfSummarySporicidal surface disinfection is recommended to control transmission of Clostridium difficile in healthcare facilities. EN 17126 provides a method to dete...
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
ConclusionUse of PPIs during CDI treatment in elderly patients is associated with decreased 180-day mortality. Although use of PPIs has been associated with an increased risk of CDI, it appears to be protective against mortality when used during the treatment phase.
Source: Gut Pathogens - Category: Microbiology Source Type: research
Objectives: To compare the impact of the use of oral antibiotics (OAB) with or without mechanical bowel preparation (MBP) on outcome in elective colorectal surgery. Summary Background Data: Meta-analyses have demonstrated that MBP does not impact upon postoperative morbidity or mortality, and as such it should not be prescribed routinely. However, recent evidence from large retrospective cohort and database studies has suggested that there may be a role for combined OAB and MBP, or OAB alone in the prevention of surgical site infection (SSI). Methods: A meta-analysis of randomized controlled trials and cohort studi...
Source: Annals of Surgery - Category: Surgery Tags: META-ANALYSES Source Type: research
Abstract Diagnostic tests favoured to detect C. difficile infections (CDI) have undergone successive changes. The problem of over-diagnosis with polymerase chain reaction (PCR) testing is recognized in the clinical setting; here we discuss the parallel of the clinical trial setting. We summarize and discuss four examples of the impact of method used to diagnose CDI on clinical trial outcomes. Bezlotoxumab, a human monoclonal antibody neutralizing toxin B, was found to be protective against recurrent CDI (rCDI) in clinical trials. A post hoc analysis showed that the magnitude of the relative reduction in rCDI rates...
Source: Anaerobe - Category: Microbiology Authors: Tags: Anaerobe Source Type: research
ConclusionsOur study showed that PPI use was associated with an increased risk of developing CDI and the risk of CDI was dose dependent. Therefore, PPIs should only be used at proper doses and only for the necessary indications to avoid CDI risk.
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
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