'She will go on': How organ donation is helping one man grieve his wife's death

Phil Gardner's wife, Mabel, died of a heart attack in December 2018. He hopes more people will be open to organ donation after hearing her story.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/Nova Scotia Source Type: news

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CONCLUSION: Typhaneoside regulates IL-6 and TNF-α as well as MMP-2 and MMP-9 in rats with heart failure after myocardial infarction. Typhaneoside can improve cardiac morphological structure and myocardial remodeling and enhance heart function. It may mediate autophagy inhibition in the cardiomyocyte anoxia/reoxygenation (A/R) pathway through the PI3K/Akt/mTOR autophagy transduction pathway. PMID: 31201434 [PubMed - as supplied by publisher]
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
Conclusion: Mirt2 was elevated in IFN-γ-treated SGECs and then up-regulated miR-377 in response to inflammatory lesions. Mechanically, in synergy with miR-377 Mirt2 blocked IFN-γ-evoked activation of NF-κB and JAK/STAT signalling pathway. PMID: 31198060 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Publication date: Available online 14 June 2019Source: Pharmacological ResearchAuthor(s): Yang Yu, Huibin Liu, Di Yang, Fang He, Ye Yuan, Jing Guo, Juan Hu, Jie Yu, Xiuqing Yan, Shuo Wang, Zhimin DuAbstractAloe-emodin (AE) is an anthraquinone derived from rhubarb and has a variety of pharmacological actions. However, the role of AE in regulating ischemic heart diseases is still unclear. The present study investigated the effect of AE on cardiac injuries induced by myocardial infarction (MI) in vivo and oxidative insults in vitro and explored the mechanisms involved. TUNEL and Flow cytometry were performed to measure cell a...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Sex-specific outcome data following myocardial infarction (MI) are inconclusive with some evidence suggesting association of female sex and increased major adverse cardiac events (MACE). Since mechanistic principles remain elusive, we aimed to quantify the underlying phenotype using cardiovascular magnetic resonance (CMR) quantitative deformation imaging and tissue characterisation.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
The objective of this study was to investigate the vulnerability of hearts with aging, LVH, diabetes, and pregnancy to ischemic insult and their response to pacing postconditioning- (PPC-) induced heart protection. Methods: Hearts isolated from aged, spontaneously hypertensive and diabetic male and female rats and hearts from pregnant female rats (n=8 per group) were subjected to coronary occlusion followed by reperfusion using a modified Langendorff system. Hemodynamics data were computed digitally, and cardiac damage was accessed by measurements of infarct size and cardiac enzyme release. Results: There were no...
Source: Cardiology Research and Practice - Category: Cardiology Authors: Tags: Cardiol Res Pract Source Type: research
Conclusions: PN-F demonstrated a potential herb to treat rats with myocardial infarction through promoting angiogenesis and inhibition of apoptosis in the infarct area. PMID: 31192006 [PubMed]
Source: Cardiology Research and Practice - Category: Cardiology Authors: Tags: Cardiol Res Pract Source Type: research
Conclusion: The results showed that circulating microRNA-499 is a reliable biomarker for diagnosing AMI patients. PMID: 31191754 [PubMed - in process]
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Publication date: Available online 14 June 2019Source: Respiratory Medicine Case ReportsAuthor(s): Takashi Ishiguro, Keisuke Matsuo, Shinya Fujii, Noboru TakayanagiAbstractA 58-year-old man with previous myocardial infarction presented to our hospital with fever, cough, and dyspnea. PCR testing with nasopharyngeal swabs confirmed influenza virus infection, and enhanced computed tomography and transthoracic echocardiography revealed bilateral ground-glass opacities and consolidation, deep venous thrombosis, acute pulmonary artery embolism, and acute arterial embolism that appeared to originate from thrombus in the left vent...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
(Natural News) Even the slightest brush with high blood pressure can be enough to scare many people into taking blood pressure medication. After all, high blood pressure can lead to heart disease and raise your risk of heart attack or stroke. However, researchers have found an even better way to get your blood pressure under...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Publication date: Available online 13 June 2019Source: The LancetAuthor(s): Tuomas T Rissanen, Sanna Uskela, Jaakko Eränen, Pirjo Mäntylä, Annika Olli, Hannu Romppanen, Antti Siljander, Mikko Pietilä, Mikko J Minkkinen, Jerry Tervo, Jussi M Kärkkäinen, Aija Vatanen, Anssi Perälä, Miriam Müller, Pekka Porela, Eeva PalojokiSummaryBackgroundThe optimal technique of percutaneous coronary intervention in patients at high bleeding risk is not known. The hypothesis of the DEBUT trial was that percutaneous coronary intervention with drug-coated balloons is non-inferior to percutaneous c...
Source: The Lancet - Category: General Medicine Source Type: research
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