Harmful neutrophil subsets in patients with ischemic stroke: Association with disease severity

Conclusion Altogether, our results indicate that during acute IS, the inflammatory properties of circulating neutrophils rise, associated with the expansion of harmful neutrophil subsets. These changes in neutrophil homeostasis, associated with disease severity, may play an instrumental role by contributing to systemic inflammation and to the blood-brain barrier breakdown. Our findings highlight new potential therapeutic approaches of stroke by rebalancing the ratio of senescent to immunosuppressive neutrophils or decreasing reverse neutrophil transmigration or both.

http://nn.neurology.org/cgi/content/short/6/4/e571?rss=1

Source: Neurology Neuroimmunology and Neuroinflammation - May 14, 2019 Category: Neurology Authors: Weisenburger-Lile, D., Dong, Y., Yger, M., Weisenburger, G., Polara, G. F., Chaigneau, T., Ochoa, R. Z., Marro, B., Lapergue, B., Alamowitch, S., Elbim, C. Tags: All Immunology, Infarction Article Source Type: research