EASL NAFLD Summit 2019, Sevilla, Spain

Source: Journal of Hepatology - Category: Gastroenterology Source Type: research

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Abstract Obesity is commonly associated with nonalcoholic fatty liver (NAFL), a benign condition characterized by hepatic lipid accumulation. However, NAFL can progress in some patients to nonalcoholic steatohepatitis (NASH) and then to severe liver lesions including extensive fibrosis, cirrhosis and hepatocellular carcinoma. The entire spectrum of these hepatic lesions is referred to as nonalcoholic fatty liver disease (NAFLD). The transition of simple fatty liver to NASH seems to be favored by several genetic and environmental factors. Different experimental and clinical investigations showed or suggested that o...
Source: Advances in Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Adv Pharmacol Source Type: research
Conclusion SGLT-2i treatment improved the liver function test results and reduced the body weight in NAFLD patients over a period of 12-24 months. This improvement was greater in patients with higher ALT values at baseline than in those with lower values. PMID: 31308341 [PubMed - in process]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conclusion: The presence of the PNPLA3 G allele is associated with a risk of NAFLD. Our study shows that subjects with variant PNPLA3 are not only at increased risk for the development and progression of NAFLD, but also have increased insulin resistance. PMID: 31304703 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver illness with a genetically heterogeneous background that can be accompanied by considerable morbidity and attendant health care costs. The pa...
Source: BMC Medicine - Category: Internal Medicine Authors: Tags: Research article Source Type: research
Obesity-associated inflammation stems from a combination of cell-intrinsic changes of individual immune cell subsets and the dynamic crosstalk amongst a broad array of immune cells. Although much of the focus of immune cell contributions to metabolic disease has focused on adipose tissue-associated cells, these potent sources of inflammation inhabit other metabolic regulatory tissues, including liver and gut, and recirculate to promote systemic inflammation and thus obesity comorbidities. Tissue-associated immune cells, especially T cell subpopulations, have become a hotspot of inquiry based on their contributions to obesi...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Source: Archives of Physiology and Biochemistry - Category: Physiology Authors: Source Type: research
ConclusionsNAFLD is a dynamic liver disease with varying degrees of progression and regression. T2DM was strongly associated with fibrosis progression. Non-invasive fibrosis scores such as AST/ALT ratio, FIB-4 score and NAFLD fibrosis score can identify those at risk of fibrosis progression.
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
In this issue, Srivastava et al. evaluated a pathway for the management of patients with non-alcoholic fatty liver disease (NAFLD), using blood tests to stratify patients in primary care in order to improve detection of cases of advanced fibrosis and cirrhosis. They studied 3,000 patients seen in primary care using a 2-step algorithm combining the use of FIB-4 followed by the ELF ™ test if required. Use of this approach detected 5-fold more cases of advanced fibrosis and cirrhosis. Unnecessary referrals from primary care to secondary care fell by 70–80%.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Editorial Desk Source Type: research
Source: Journal of Hepatology - Category: Gastroenterology Source Type: research
This study aimed to evaluate the association between serum vitamin D levels and nonalcoholic fatty liver disease (NAFLD) parameters, such as metabolic syndrome (MS), inflammatory cytokines (tumor necrosis fact...
Source: BMC Gastroenterology - Category: Gastroenterology Authors: Tags: Research article Source Type: research
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