Low frequency of positive antithyroid antibodies is observed in patients with thyroid dysfunction related to immune check point inhibitors

ConclusionsIn our sample of 11 Caucasian patients with thyroid dysfunction related with anti-PD1, we found low frequency of ATA positive titers, comparable to other recent reports in others ethnicities, which could suggest that silent thyroiditis due to pembrolizumab or nivolumab has a different pathogenesis from the classical autoimmune spontaneous thyroiditis. Further investigations are required to completely understand the immune mechanisms involved.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research

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We present a young female patient (36 years) admitted to Department of Ophthalmology due to visual loss on the left eye. Magnetic resonance imaging showed demyelinating lesions in frontal and parietal lobe, periventricularly, in mesencephalon and right cerebellar hemisphere, and left optic neuritis; magnetic resonance angiography was normal. The patient's history revealed renal dysfunction, hypothyroidism, and miscarriage in the 6th month of pregnancy due to eclampsia, and Fabry disease in family (mother and two sisters). She was transferred to the Department of Neurology for further evaluation of the demyelinating disorde...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
We present a case where nocardial abscesses of lung and brain were initially suspected as lung cancer with brain metastases. The patient was treated with a combination of surgical resection and antimicrobial therapy with good outcome. PMID: 31969769 [PubMed - in process]
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
ous M Abstract Oral disorders were observed in children with congenital hypothyroidism, lately apparent because of difficulties of feeding, swallowing disorders, and macroglossia. Macroglossia was also a component of the severe acquired myxedema, particularly observed in hypothyroidism related to autoimmune atrophic thyroiditis beyond menopause. Lingual ectopy in children and adults could determine respiratory gene or swallowing difficulties, and were detectable by visual examination and the endobuccal touch. Expression of these events was completely minimized since the neonatal screening of congenital hypothyroid...
Source: Presse Medicale - Category: General Medicine Authors: Tags: Presse Med Source Type: research
GOOP is at it again with the dangerous medical advice. This time they are leaving the vagina alone and focusing their dangerous energy vibrations on your thyroid. The article that caught my eye and my disgust is about iodine and the medical “expert” is a self-described medical medium (yes, you read that correctly) named Anthony William. What, pray tell, is a medial medium? Well, Mr. William claims he “was born with the unique ability to converse with a high-level spirit who provides him with extraordinarily accurate health information that’s often far ahead of its time.” That’s right, he...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
AbstractIntroductionThe aim of this study was to evaluate the association of breast cancer with thyroid diseases. Many authors have already studied the possible relationship between these two diseases, but the results are nowadays conflicting.Materials and methodsOur study examining 867 patients with breast cancer (862 women and 5 men, average age  = 61 years old) of whom 141 also had thyroid disease evaluated the recurrence of thyroid diseases and their association with different types of breast cancer. Statistical analyses were performed using SPSS software for Windows; we used nonparametric tests (Chi-squ...
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
By: Dr. Alan Christianson When someone you know is living with hypothyroidism, it can be tempting to think that if only the doctor would prescribe an extra helping of thyroid hormone, your friend or loved one would feel so much better and would enjoy life more. And in some cases, an extra helping might be in order. In other cases, not so much. Too much thyroid hormone can actually be dangerous, which is why doctors are loathe to bump the levothyroxin dosage up an extra 25 micrograms or so for one of their patients who's still experiencing hypothyroid symptoms. Tests always come first, and there's a good reason for that....
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
CONCLUSIONS: The number of papers in clinical thyroid disease is expanding rapidly, with more than a thousand papers published annually over the last decade. Research papers on thyroid nodules and cancer accounted for 51% of all clinical thyroid disease-related papers. More RCTs have been published in the last few years, portending a bright future for clinical thyroidology. PMID: 27266559 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
CONCLUSIONS: Further randomized trials are needed to expand our knowledge of physiologic changes in thyroid function during the pregnancy and to reveal mechanisms by which thyroid autoimmunity in euthyroid women affect fertility, especially the success of assisted reproductive technology in achieving the same and validity of levothyroxine administration in thyroid autoimmunity positive women. PMID: 25855922 [PubMed - indexed for MEDLINE]
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Tags: Eur Rev Med Pharmacol Sci Source Type: research
This study consisted of 113 patients
Source: Pediatric Radiology - Category: Radiology Source Type: research
Exp Clin Endocrinol Diabetes 2015; 123: 386-393DOI: 10.1055/s-0035-1554714Vitamin D’s canonical role are its effects exerted on the musculoskeletal system. In the last decades the importance of this hormone has been studied in the context of extraskeletal health. Hypovitaminosis D and several polymorphic variants of genes coding proteins crucial in the transport, metabolism and effects of vitamin D have been associated with negative health outcomes.In this review the current state of knowledge on the role of vitamin D in thyroid disorders is presented. The review is based on a literature search of the PubMed database...
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Tags: Review Source Type: research
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