Efficacy analysis of medical and surgical treatments in chronic kidney disease patients with secondary hyperparathyroidism

ConclusionAlthough the progress of medical treatment is changing rapidly, surgical treatment is still an effective way to control serum iPTH and calcium chronically for SHPT patients. Complex SHPT patients can also receive satisfied effect by surgical treatment, without apparently increasing the risk of complications.
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research

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AbstractSecondary and tertiary hyperparathyroidism is an important problem of chronic kidney disease. Brown tumor is a benign, unusual, reactive lesion as a result of disturbed bone remodeling, from long-standing increase in parathyroid hormone level. Brown tumors may cause morbidity due to pressure symptoms on neural structures and spontaneous bone fractures. Herein, we presented a peritoneal dialysis patient with tertiary hyperparathyroidism under calcand calcitriol treatment for 4  years due to refusing of the parathyroidectomy operation. She admitted to hospital for sudden onset back pain with difficulty in gait a...
Source: CEN Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 2 May 2019Source: Urology Case ReportsAuthor(s): Amulya Cherukumudi, Suraj Hegde, T.P. Rajeev, Narendra Pai, Amit Kumar, Gaurav KalraAbstractGangrene of the penis in patients with chronic kidney disease undergoing haemodialysis is a rare occurrence. Such patients often have associated comorbidities such as type II diabetes mellitus and systemic hypertension, along with secondary hyperparathyroidism leading to dystrophic calcification. These conditions accelerate the process of atherosclerosis, which, along with calcium deposition, causes partial or complete obstruction of the blood vessel...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Calcimimetics are widely used in patients on dialysis to treat secondary hyperparathyroidism. Our current view is that bone effects are only indirect through parathyroid hormone suppression. However, because bone cells express the calcium-sensing receptor, direct calcium-sensing receptor –mediated effects are also possible. New experimental data demonstrate direct anabolic bone actions of calcimimetics, independent of parathyroid hormone suppression. Because these effects could be clinically useful, further studies are necessary to confirm the validity of this observation.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
The link between age-related kidney dysfunction and cognitive impairment is an interesting one, particularly in the context of research into klotho, which has functions in both the kidney and the brain, and has been shown to extend life and improve cognitive function in animal studies. It isn't completely clear as to which of these areas of the body is most important to the noted benefits to cognitive function in animal models, produced via various strategies for klotho overexpression. The most recent research on this topic tends to suggest that the mechanisms are indirect, involving many organ systems, rather than being a...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Authors: Lioufas N, Hawley CM, Cameron JD, Toussaint ND Abstract Chronic kidney disease (CKD) is associated with excess cardiovascular mortality, resulting from both traditional and nontraditional, CKD-specific, cardiovascular risk factors. Nontraditional risk factors include the entity Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) which is characterised by disorders of bone and mineral metabolism, including biochemical abnormalities of hyperphosphatemia and hyperparathyroidism, renal osteodystrophy, and vascular calcification. Increased arterial stiffness in the CKD population can be attributed amongs...
Source: International Journal of Hypertension - Category: Cardiology Tags: Int J Hypertens Source Type: research
Authors: Gameiro J, Duarte I, Outerelo C, Lopes JA Abstract Mineral bone disorder is a common feature of chronic kidney disease. Lion face syndrome is rare complication of severe hyperparathyroidism in end-stage renal disease patients, which has been less commonly reported due to dialysis and medical treatment advances in the last decade. The early recognition of the characteristic facial deformity is crucial to prompt management and prevent severe disfigurement. The authors present a rare case of severe hyperparathyroidism presenting with lion face syndrome and bone fractures. PMID: 30720853 [PubMed - as supplied by publisher]
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
This study had double-blind and open-label phases. Eligible patients aged 6 –
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Conclusions: rs11063112 was associated with HF and cardiovascular mortality in patients receiving dialysis with moderate to severe secondary hyperparathyroidism.Am J Nephrol 2019;49:125 –132
Source: American Journal of Nephrology - Category: Neurology Source Type: research
CONCLUSIONS: rs11063112 was associated with HF and cardiovascular mortality in patients receiving dialysis with moderate to severe secondary hyperparathyroidism. PMID: 30669147 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: Am J Nephrol Source Type: research
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