Association of autoimmunity and cancer: An emphasis on proteolytic enzymes

Publication date: Available online 14 May 2019Source: Seminars in Cancer BiologyAuthor(s): Shams Tabrez, Nasimudeen R. Jabir, Mohammad Imran Khan, Mohd Shahnawaz Khan, Shazi Shakil, Ali Nasir Siddiqui, Syed Kashif Zaidi, Bakrudeen Ali Ahmed, Mohammad Amjad KamalAbstractCancer and autoimmune diseases are the two devastating conditions that together constitute a leading health problem worldwide. The rising burden of these disorders in the developing world demands a multifaceted approach to address the challenges it poses. Understanding the root causes and specific molecular mechanisms by which the progression of the diseases takes place is the need of the hour. A strong inflammatory background and common developmental pathways, such as activation of immune cells, proliferation, increased cell survival and migration which are controlled by growth factors and inflammatory cytokines have been considered as the critical culprits in the progression and complications of these disorders. Enzymes are the potential immune modulators which regulate various inflammatory events and can break the circulating immune complexes via macrophages production. In the current manuscript, we have uncovered the possible role of proteolytic enzymes in the pathogenesis and progression of cancer and autoimmune diseases. In the light of the available scientific literature, we advocate in-depth comprehensive studies which will shed light towards the role of proteolytic enzymes in the modulation of inflamma...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research