Sequence and expression analysis of cardiac ryanodine receptor 2 in broilers died from sudden death syndrome.

In conclusion, susceptibility to lethal cardiac arrhythmia in SDS may be associated with specific changes in intracellular Ca2+ cycling components such as RYR2 due to mutation and dysregulation. Finding the probable association of SDS with gene defects can be applied to select for chickens with lower susceptibility to SDS and decrease the poultry industry losses due to SDS mortality. PMID: 31081346 [PubMed - as supplied by publisher]
Source: Avian Pathology - Category: Pathology Authors: Tags: Avian Pathol Source Type: research

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In this study, we detected for just the second time a SINV infection in a diseased wild bird (common wood pigeon) from Central Europe. SINV was isolated by cell culture and the complete SINV genome sequence was determined. Phylogenetic analyses revealed a close affiliation to SINV genotype I with a high similarity to human isolate sequences from Finland, Sweden and Russia. The isolate was genetically distinct from the first avian isolate suggesting the circulation of at least two different SINV strains in Germany.In order to reveal the infection frequency in SINV positive mosquito regions 749 bird blood samples were assaye...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Authors: Mayr F, Vieider C, Temml V, Stuppner H, Schuster D Abstract Interference with the hERG potassium ion channel may cause cardiac arrhythmia and can even lead to death. Over the last few decades, several drugs, already on the market, and many more investigational drugs in various development stages, have had to be discontinued because of their hERG-associated toxicity. To recognize potential hERG activity in the early stages of drug development, a wide array of computational tools, based on different principles, such as 3D QSAR, 2D and 3D similarity, and machine learning, have been developed and are reviewed ...
Source: Progress in the chemistry of organic natural products - Category: Chemistry Tags: Prog Chem Org Nat Prod Source Type: research
Publication date: Available online 7 October 2019Source: Pathology - Research and PracticeAuthor(s): Dominik Gross, Christina LaursAbstractThe Jewish pathologist Carl Julius Rothberger (1871–1945) is undoubtedly one of the most important representatives of his field. His studies on atrial fibrillation, the bundle branch block and arrhythmia perpetua in particular secured him a place in medical history. Rothberger also gave the name to an agar used to prove the neutral red reduction of salmonella (Rothberger-Scheffler agar).While Rothberger’s name is well known in pathology, his biography and his experiences of ...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
ConclusionsThese findings provided strong evidences that TGD intervention ameliorated interstitial fibrosis, myocyte hypertrophy and gap junction expression in the IBZ, attenuated left ventricular remodeling and dysfunction, and reduced vulnerability to tachyarrhythmia. TGD inhibited IBZ remodeling by its inhibition effect on myofibroblasts differentiation.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 16 October 2019Source: Canadian Journal of CardiologyAuthor(s): Sattler Katherine, El-Battrawy Ibrahim, Gietzen Thorsten, Kummer Marvin, Lang Siegfried, Zhou Xiao-bo, Behnes Michael, Borggrefe Martin, Akin IbrahimAbstractBackgroundCardiogenic shock (1) is a severe complication of myocardial infarction (MI) or of takotsubo syndrome. For both diseases, CS is related to a worse long term outcome. Outcome of CS has not been studied in a direct comparison of MI patients and TTS patients.Methods and ResultsMortality and cardiovascular complications were compared in patients presenting with CS b...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
ConclusionThe IECF is simple, particularly at reoperations, in borderline patients and those needing concomitant intracardiac procedures. Early results are promising. These patients need constant surveillance.
Source: Indian Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
The transient receptor potential ankyrin 1 (TRPA1) channel is a calcium-permeable nonselective cation channel in the plasma membrane that belongs to the transient receptor potential (TRP) channel superfamily. Recent studies have suggested that the TRPA1 channel plays an essential role in the development and progression of several cardiovascular conditions, such as atherosclerosis, heart failure, myocardial ischemia–reperfusion injury, myocardial fibrosis, arrhythmia, vasodilation, and hypertension. Activation of the TRPA1 channel has a protective effect against the development of atherosclerosis. Furthermore, TRPA1 c...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Campylobacter jejuni (C. jejuni) are able to colonise and infect domestic poultry and also pose a risk for humans. The aim of this study was to determine the extent of genotypic diversity among C. jejuni isolates recovered from avian and human sources in Egypt. Furthermore, the short variable region (SVR) of flagellin A (flaA) gene was analysed for the presence of allelic variants. Our results showed that C. jejuni isolates differ in their capacity to harbour each of the virulence genes alone or when present in various combinations. The flaA gene was detected in all C. jejuni strains and none of the strains had all the stu...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
ConclusionsWire ‐guided pericardial puncture exhibits better safety and similar success rates to contrast‐guided technique with a trend towards less complications.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ‐ CLINICAL Source Type: research
AbstractAtrial fibrillation (AF) is common in patients with obesity and diabetes; the arrhythmia (if long ‐standing) is typically managed by rate‐control and anticoagulation. However, the coexistence of these two metabolic disorders complicates therapeutic options for rate‐control. The likely pathogenesis of AF in these patients is an expansion of epicardial adipose tissue, whose inflammation is t ransmitted to the left atrium causing electromechanical remodeling. However, this same process is also transmitted to the left ventricle, impairing its distensibility and its ability to tolerate volume, leading to heart fai...
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: COMPREHENSIVE REVIEWS Source Type: research
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