Suppression of PDGF Induces Neuronal Apoptosis after Neonatal Cerebral Hypoxia and Ischemia by Inhibiting P-PI3K and P-AKT signaling pathways.

In conclusion, PDGF suppression aggravated neuronal dysfunction, and the underlying mechanism is associated with inhibiting the phosphorylation of P-PI3K and P-AKT. Together, PDGF regulating PI3K and AKT may be an important panel in HIE events and therefore may provide possible strategy for the treatment of HIE in future clinic trail.
PMID: 31082354 [PubMed - as supplied by publisher]

Source: Brain Research - May 9, 2019 Category: Neurology Authors: Xiong LL, Xue LL, Jiang Y, Ma Z, Jin Y, Wang YC, Wang YY, Xia QJ, Zhang Y, Hu Q, Liu J, Wang TH Tags: Brain Res Source Type: research