Exenatide Alleviates Mitochondrial Dysfunction and Cognitive Impairment in the 5 ×FAD Mouse Model of Alzheimer's Disease.

Exenatide Alleviates Mitochondrial Dysfunction and Cognitive Impairment in the 5×FAD Mouse Model of Alzheimer's Disease.
Behav Brain Res. 2019 May 10;:111932
Authors: Jingjing A, Yu Z, Mengjun Z, Yunzhen X, Sujie K, Libin L, Xiaodong P, Zhou C
Abstract
The role of mitochondrial dysfunction has been well-documented in Alzheimer's disease (AD). Glucagon-like peptide 1 (GLP-1) receptor agonists are being utilized as neuroprotectants in the treatment of various neurological disorders, including AD. We conducted this study to explore the effects of exenatide (a GLP-1 receptor agonist) on β-amyloid plaque (Aβ)-induced cognitive impairment and mitochondrial dysfunction in 5xFAD transgenic mice. Spatial memory test showed that exenatide administration (100 µg/kg twice per day) prevented cognitive decline after 16 weeks of treatment. Aβ1-42 deposition and synapse damage in the hippocampus was significantly alleviated. Furthermore, exenatide treatment can improve mitochondrial morphology, relieve oxidative damage, correct mitochondrial energy crisis, and normalize mitochondrial dynamics. These findings suggest that exenatide, which has already been applied in clinical medicine, may be a promising agent for AD therapy via mitochondrial protection.
PMID: 31082410 [PubMed - as supplied by publisher]

Source: Behavioural Brain Research - May 9, 2019 Category: Neurology Authors: Jingjing A, Yu Z, Mengjun Z, Yunzhen X, Sujie K, Libin L, Xiaodong P, Zhou C Tags: Behav Brain Res Source Type: research