Haematological aspects of the gut flora.

[Haematological aspects of the gut flora]. Orv Hetil. 2019 May;160(20):774-779 Authors: Szerafin L, Jakó J Abstract The relationship between the gut flora and various diseases (obesity, diabetes mellitus, metabolic disorders, allergic and autoimmune diseases, inflammatory bowel diseases, liver failure, infections, certain neuropsychiatric disorders, tumors) has been highlighted in recent years. Depletion of microbiotics inhibits bone marrow healing. Infections and their antibiotic treatment may also affect hematopoiesis. Intestinal flora may also affect the severity of the graft-versus-host disease and may also play a role in the pathogenesis of immunthrombocytopenia through the T-regulator cells. The study summarizes the features of the gut flora, the effects of microbiotics on bone marrow healing, the course of infections, allogeneic bone marrow transplantation, graft-versus-host disease, lymphoma and the results of related research and therapeutic options. The authors briefly discuss the possible linkage between intestinal flora and immunthrombocytopenia and the effectiveness of the immunotherapy of tumors and its effect on the von Willebrand-factor synthesis. They draw attention on the importance of maintaining microbiotics diversity. Orv Hetil. 2019; 160(20): 774-779. PMID: 31081358 [PubMed - in process]
Source: Orvosi Hetilap - Category: General Medicine Authors: Tags: Orv Hetil Source Type: research

Related Links:

The presence of tumor-infiltrating T cells is associated with favorable patient outcomes, yet most pancreatic cancers are immunologically silent and resistant to currently available immunotherapies. Here we show using a syngeneic orthotopic implantation model of pancreatic cancer that Pik3ca regulates tumor immunogenicity. Genetic silencing of Pik3ca in KrasG12D/Trp53R172H-driven pancreatic tumors resulted in infiltration of T cells, complete tumor regression, and 100% survival of immunocompetent host mice. By contrast, Pik3ca-null tumors implanted in T cell–deficient mice progressed and killed all of the animals. Ad...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
[UN] An estimated 820 million people did not have enough to eat in 2018, up from 811 million in the previous year, which is the third year of increase in a row. This underscores the immense challenge of achieving the Sustainable Development Goal of Zero Hunger by 2030, says a new edition of the annual The State of Food Security and Nutrition in the World report released today.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[Thomson Reuters Foundation] Our food systems are distorted, and unless bolder actions are taken soon to fix them, humanity is at grave risk of increasing hunger, obesity and diet-related illnesses. It is a stark warning, but one that must be heeded if all countries are to fulfil their commitment to achieve the Sustainable Development Goal number 2 - eradicating hunger and all forms of malnutrition.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Abstract Lysosomal diseases (LDs), also known as lysosomal storage diseases (LSDs), are a heterogeneous group of conditions caused by defects in lysosomal function. LDs may result from deficiency of lysosomal hydrolases, membrane-associated transporters or other non-enzymatic proteins. Interest in the LD field is growing each year, as more conditions are, or will soon be treatable. In this article, we review the diagnosis of LDs, from clinical suspicion and screening tests to the identification of enzyme or protein deficiencies and molecular genetic diagnosis. We also cover the treatment approaches that are currently avail...
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
Conclusion: The high prevalence of musculoskeletal pain demonstrates the need for strategies aimed at preventing this aggravation still in the academic setting.RESUMEN Objetivo: Verificar la prevalencia y factores asociados con el dolor musculoesquel ético en estudiantes de pregrado del área sanitaria. Método: Estudio transversal, realizado en con estudiantes de pregrado de una universidad del Sur de Brasil en el período de abril a julio de 2017. Se empleó el cuestionario de caracterización de los estudiantes y la versión brasileña del Standardized Nordic Questionnair...
Source: Revista da Escola de Enfermagem da USP - Category: Nursing Source Type: research
ABSTRACT Multiple sclerosis (MS) is an autoimmune, inflammatory, and degenerative disease of the central nervous system. Axonal degeneration is triggered by inflammation and is the pathological substrate of progressive disability in patients with MS. Therapeutic interventions can reduce inflammatory activity, thus delaying neurodegeneration and the progression of disability. Disease activity and neurodegeneration are assessed mainly through clinical evaluation and magnetic resonance imaging. These measures lack sensitivity and accuracy, so new biomarkers are necessary. Several markers have been studied and to date the most...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
ConclusionWe observed a high frequency of RV dysfunction in a sample of potential heart donors. However, the temporal evolution of RV dysfunction, the hemodynamic predictors of RV dysfunction, as well the link between donor RV dysfunction and recipient outcomes need to be assessed with further prospective studies.
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
CONCLUSION: In this nationwide cohort study, the 1-year risk of pelvic sepsis following primary IPAA for ulcerative colitis increased 4-fold from 1996 to 2013. See Video Abstract at http://links.lww.com/DCR/A956.
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contributions: Inflammatory Bowel Disease Source Type: research
CONCLUSION: An endoscopic decompression was required to allow a laparoscopic treatment, and a bilateral pouchopexy was needed to avoid recurrence. This standardized approach might be a good treatment option, and we are awaiting additional follow-up to determine its long-term durability. In addition to the already described risk factors (minimally invasive technique, female sex, and low BMI), an anterior positioning of the pouch mesentery might be a potential risk factor as well for pouch volvulus. However, these observations should be carefully interpreted, considering the small number of cases.
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Technical Notes Source Type: research
Unfortunately there is a mistake in the presentation of the affiliations in this paper.
Source: Diabetologia - Category: Endocrinology Source Type: research
More News: Allergy & Immunology | Autoimmune Disease | Bone Marrow Transplant | Brain | Diabetes | Diabetes Mellitus | Eating Disorders & Weight Management | Endocrinology | General Medicine | Immunotherapy | Inflammatory Bowel Disease | Liver | Liver Transplant | Lymphoma | Neurology | Obesity | Study | Transplants | Urology & Nephrology | von Willebrand Disease